Linking retroelements to autoimmunity

Cell
Vijay G Bhoj, Zhijian J Chen

Abstract

In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.

References

Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Aug 30, 2008·Cell·Daniel B StetsonRuslan Medzhitov

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Citations

Jun 8, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Björn Rabe
Feb 5, 2013·Nature Structural & Molecular Biology·Benjamin HerquelIrwin Davidson
Jul 5, 2011·Retrovirology·Richard D Sloan, Mark A Wainberg
Aug 12, 2014·Seminars in Immunopathology·Tony N Marion, Arnold E Postlethwaite
Jul 21, 2009·DNA Repair·Chuan-Jen WangYung-Chi Cheng
Jul 24, 2008·Journal of Cellular Biochemistry·Gary S SteinSayyed K Zaidi
Feb 21, 2009·The FEBS Journal·Susana M Cerritelli, Robert J Crouch
May 25, 2010·Arthritis and Rheumatism·Michel NeidhartSteffen Gay
Dec 4, 2012·Autoimmunity Reviews·Yihong YaoLars Rönnblom
Jul 30, 2008·Cell·Jeffrey Fillingham, Jack F Greenblatt
Aug 6, 2019·Scandinavian Journal of Immunology·Jacek Hawiger, Jozef Zienkiewicz

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