Linking survival of HER2-positive breast carcinoma patients with surgical invasiveness

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Elda TagliabueSylvie Ménard

Abstract

The early peak of relapse in patients with breast carcinomas that overexpress HER2 oncoprotein and dissemination to the axillary lymph nodes might be related to proliferation of micrometastatic lesions induced by EGF family growth factors released at the time of surgery. If the levels of these growth factors have an impact on relapse, the survival of patients with positive nodes and HER2-positive tumours should be dependent on surgery wideness. To test this hypothesis, HER2 status of primary tumours from patients included in a randomized clinical trial addressing conservative quadrantectomy versus radical mastectomy was retrospectively analyzed. In HER2-negative patients, independently of node infiltration, and in HER2-positive patients without node infiltration, no differences in survival according to the type of surgery were observed. In patients with positive nodes and HER2-positive tumours the estimation of the time-dependent log-hazard ratios showed that radical mastectomy significantly increased early death rates (P=0.037).

References

Aug 30, 2000·Nature·C M PerouD Botstein
May 9, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T CookeP Stanton
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Aug 23, 2003·Lancet·Elda TagliabueSylvie Ménard

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Citations

Feb 14, 2008·Journal of Translational Medicine·Michele MaioGiorgio Parmiani
Mar 15, 2011·Annals of Diagnostic Pathology·Bing GuanXiaojun Zhou
Sep 11, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H M C Shantha KumaraR L Whelan
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea MerloAndrea Balsari
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara BellettiSamuele Massarut

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