Linking tumor suppression, DNA damage and the anaphase-promoting complex

Trends in Cell Biology
Peter K Jackson

Abstract

A recent study shows that the RASSF1A tumor suppressor functions as a regulator of the ordered proteolytic steps that organize mitosis. By controlling the stability of microtubules and the activity of the anaphase-promoting complex (APC), RASSF1A might provide a crucial link between mechanisms of tumor suppression and mitotic cell division. Furthermore, another recent study shows that protein kinase A, which is a key growth regulator, inhibits the APC during mitosis in yeast.

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Citations

Oct 18, 2005·Nature Reviews. Molecular Cell Biology·Walter Kolch
Apr 8, 2009·International Journal of Cancer. Journal International Du Cancer·Takeo FujitaYong Wan
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Dec 23, 2020·Cancers·Desmond R Harrell StewartGeoffrey J Clark

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