Links between atherosclerotic and periodontal disease

Experimental and Molecular Pathology
Dimitry A ChistiakovYuri V Bobryshev

Abstract

Periodontal disease (PD) and cardiovascular disease (CVD) are highly prevalent in the modern community. Both pathologies are chronic inflammatory disorders, which are influenced by multiple risk factors. In part, these factors such as age, smoking, and diabetes overlap between PD and CVD. Epidemiological studies suggest that PD is strongly associated with increased CVD risk. Biochemical and physiological analyses involving in vitro experiments, animal models, and clinical studies provided evidence for the substantial impact of periodontal pathogens, their virulence factors, and bacterial endotoxins on all general pathogenic CVD mechanisms such as endothelial dysfunction, systemic inflammation, oxidative stress, foam cell formation, lipid accumulation, vascular remodeling, and atherothrombosis. Interventional studies showed moderate beneficial effects of PD treatment on reducing systemic inflammation and endothelial dysfunction. However, no interventional studies were performed to assess whether periodontal therapy can primarily prevent CVD. In summary, current data suggest for a strong contributory role of periodontal infection to CVD but cannot provide sufficient evidence for a role of PD as a cause for cardiovascular pathology.

References

Nov 1, 1991·Journal of Clinical Periodontology·S S SocranskyS Dibart
Mar 25, 1989·BMJ : British Medical Journal·K J MattilaM J Jokinen
May 1, 1989·Journal of Dental Research·R J Gibbons
May 1, 1987·Journal of Dental Research·L V MooreR R Ranney
Jun 1, 1994·Periodontology 2000·W E Moore, L V Moore
Sep 2, 1998·Annals of Periodontology·M C Herzberg, M W Weyer
Oct 28, 1999·American Heart Journal·B Chiu
Feb 24, 2000·Journal of Periodontal Research·A Progulske-FoxY Wu
Aug 24, 2000·The American Journal of Cardiology·J ZhuS E Epstein
Sep 16, 2000·JAMA : the Journal of the American Medical Association·P P HujoelT A DeRouen
Nov 4, 2000·Journal of Periodontology·V I HaraszthyR J Genco
Sep 22, 2001·Biochimica Et Biophysica Acta·P J PussinenM Jauhiainen
Oct 2, 2001·Journal of Periodontology·B NoackE De Nardin
Feb 16, 2002·Journal of Periodontology·Sabine O GeertsEric H Rompen
Mar 13, 2002·Annals of Periodontology·H K KuramitsuW Chen
Jun 13, 2002·International Endodontic Journal·B R DornA Progulske-Fox
Feb 25, 2003·Trends in Microbiology·Alexander H RickardPauline S Handley
Oct 3, 2003·Journal of the American College of Cardiology·Michael E WidlanskyJoseph A Vita
Oct 29, 2003·Microbial Pathogenesis·Mingshan QiHoward K Kuramitsu
Dec 5, 2003·Journal of Periodontology·Satoru InagakiKatsuji Okuda
Dec 20, 2003·Current Protein & Peptide Science·N M O-Brien-SimpsonE C Reynolds
Feb 12, 2004·European Journal of Oral Sciences·Rudolf GmürBernhard Guggenheim
Feb 12, 2004·Oral Microbiology and Immunology·P I Diaz, A H Rogers

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Citations

Dec 12, 2017·Journal of Cellular Physiology·Tung-Sheng ChenChih-Yang Huang
Jun 15, 2018·The Journal of Cardiovascular Nursing·Seon Young HwangJungsoon Choi
Mar 8, 2019·Bioscience Reports·Stefan LjunggrenJohanna Lönn
Oct 23, 2019·Journal of Immunology Research·Carolyn G J MoonenBruno G Loos
Jun 17, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Endah A T WulandariPatricia Price
Nov 20, 2016·International Dental Journal·Ira B Lamster, Michael Pagan
Jul 7, 2017·Journal of Periodontal & Implant Science·Sa-Beom ParkJong-Tae Park
Jan 25, 2018·Mediators of Inflammation·S MemmertJ Deschner
Jun 25, 2020·Brazilian Oral Research·Fernanda Cristina Figueira TeixeiraPriscila Maria Stolses Bergamo Francisco
Dec 15, 2019·Dentistry Journal·Luca FiorilloMarco Cicciù
Nov 24, 2019·Innate Immunity·Carolyn Gj MoonenBruno G Loos
May 16, 2020·Mediators of Inflammation·Andressa V B NogueiraJoni A Cirelli
Jun 13, 2018·Scientific Reports·Trung Dung TranEmmanuel Lesaffre
Apr 25, 2020·Scientific Reports·Aline Barbosa RibeiroHelio Cesar Salgado
Sep 12, 2019·Frontiers in Aging Neuroscience·Büin AdamsEtheresia Pretorius
Aug 9, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dimitry A ChistiakovAlexander N Orekhov
Nov 8, 2020·Scientific Reports·Aline Barbosa RibeiroHelio Cesar Salgado
Feb 2, 2021·Frontiers in Physiology·Oindrila PaulShampa Chatterjee
Apr 27, 2021·Journal of Dental Research·J H RhoH R Park
Jul 9, 2021·Journal of Inflammation Research·Eileen MoritzBirte Holtfreter
Jul 6, 2021·BioMed Research International·Verica PavlicDanijela Staletovic
Jul 25, 2021·International Journal of Environmental Research and Public Health·Kun-Tsung LeeYung-Kai Huang
Jul 31, 2020·Current Neuropharmacology·Jerzy LeszekGjumrakch Aliev

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