Apr 1, 2020

The adaptive response to long term nitrogen starvation in Escherichia coli requires the breakdown of allantoin

BioRxiv : the Preprint Server for Biology
Rene L WarrenInanc Birol


Bacteria initially respond to conditions that attenuate their growth by eliciting large-scale transcriptional changes. The accompanying changes in gene expression and metabolism allow the bacterial cells to effectively adapt to the growth attenuated state. How the transcriptome subsequently changes as growth attenuation ensues is not well understood. We used nitrogen (N) starvation as a model nutrient starvation condition to study the transcriptome of growth attenuated Escherichia coli. The results reveal that the transcriptome of nitrogen starvation-induced growth attenuated E. coli remains dynamic and perturbations to it compromise the viability of growth attenuated bacteria and their ability to effectively recover growth when N starvation conditions become alleviated. We further reveal that, over time, N starvation-induced growth attenuated bacteria rely on the degradation of allantoin for optimal growth recovery when N becomes replenished. This study provides insights into the temporally coordinated adaptive responses that occur in E. coli experiencing sustained N starvation.

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Mentioned in this Paper

Computer Software
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Genome Assembly Sequence
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