PMID: 9184648Jun 1, 1997Paper

Linomide-induced suppression of experimental autoimmune neuritis is associated with down-regulated macrophage functions

Journal of Neuroimmunology
X F BaiH Link

Abstract

Experimental autoimmune neuritis (EAN) is a T-cell mediated autoimmune disease of the peripheral nervous system, in which macrophages and T-cells feature prominently in nerve lesions. EAN represents a counterpart to Guillain-Barré syndrome in humans. In the present study, we investigated the in vitro and in vivo effects of Linomide (LS-2616, quinoline-3-carboxamide), a synthetic immunomodulatory compound, on macrophages in relation to EAN. Linomide strongly suppressed IFN-gamma and lipopolysaccharide (LPS)-induced IL-1 beta, TNF-alpha and IL-6 mRNA expression in macrophages in vitro as demonstrated by in situ hybridisation. Linomide administered daily subcutaneously from the day of inoculation completely prevented the development of clinical symptoms of EAN. Linomide administered from day 9 post immunisation (p.i.) significantly suppressed clinical EAN. Macrophages from Linomide-treated EAN rats showed decreased IL-1 beta, TNF-alpha and IL-6 mRNA expression in response to IFN-gamma and LPS. LPS-induced nitric oxide production by macrophages was also suppressed by Linomide in vitro. Linomide, however, does not affect macrophage death and release of lactate dehydrogenase. We conclude that Linomide may exert its actions in EAN and...Continue Reading

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Citations

Dec 16, 1998·Journal of the Neurological Sciences·J ZhuG Hedlund
Feb 7, 2002·Journal of Hepatology·Daniel KlintmanHenrik Thorlacius
Jun 16, 2001·International Immunopharmacology·D J GrossS Slavin
Dec 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M ShalevI Gery
Feb 1, 2014·Expert Opinion on Therapeutic Targets·Hong-Liang ZhangJie Zhu
Mar 1, 2011·Expert Opinion on Emerging Drugs·Christa WalgaardPieter A van Doorn
Nov 8, 2016·Expert Opinion on Therapeutic Targets·Ying WangHong-Liang Zhang
Nov 20, 2018·Journal of Leukocyte Biology·Corneliu SimaMichael Glogauer

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