PMID: 9630163Jun 18, 1998Paper

Linomide suppresses acute experimental autoimmune encephalomyelitis in Lewis rats by counter-acting the imbalance of pro-inflammatory versus anti-inflammatory cytokines

Journal of Neuroimmunology
A DiabJ Zhu

Abstract

Linomide (quinoline-3-carboxamide) is a synthetic immunomodulator that suppresses several experimental autoimmune diseases. Here we report the effects of Linomide on experimental autoimmune encephalomyelitis (EAE), a CD4+ T cell-mediated animal model of multiple sclerosis (MS). EAE induced in Lewis rats by inoculation with homogenized guinea pig spinal cord and Freund's complete adjuvant was strongly suppressed by Linomide administered daily subcutaneously from the day of inoculation. Linomide dose-dependently delayed the interval between immunization and onset of clinical EAE, and reduced severity of EAE symptoms. These clinical effects were associated with dose-dependent down-modulation of myelin antigens-induced T cell responses and by suppression of the proinflammatory cytokines IFN-gamma and TNF-alpha, and upregulation IL-4, IL-10 and TGF-beta as evaluated by in situ hybridization for mRNA expression in spleen mononuclear cells and spinal cord sections. These findings suggest that Linomide could be useful in certain T cell dependent autoimmune diseases.

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Citations

Dec 16, 1998·Journal of the Neurological Sciences·J ZhuG Hedlund
Feb 7, 2002·Journal of Hepatology·Daniel KlintmanHenrik Thorlacius
Jun 16, 2001·International Immunopharmacology·D J GrossS Slavin
Feb 5, 2003·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hidefumi FukumitsuRihito Watanabe
Dec 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M ShalevI Gery
Jul 19, 2005·Expert Opinion on Investigational Drugs·Lara Teare, John Zajicek
Apr 25, 2000·Multiple Sclerosis : Clinical and Laboratory Research·I L TanF Barkhof
Nov 15, 2013·Therapeutic Advances in Neurological Disorders·Shalom HaggiagClaudio Gasperini
Jul 16, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H TuvessonJ Seidegård
Jan 29, 2000·Journal of Autoimmunity·G J Prud'homme, C A Piccirillo

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