Lipase member H frequently overexpressed in human esophageal adenocarcinomas

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Hisako IshimineAkira Kurisaki

Abstract

Esophageal cancer is one of the most frequent causes of cancer-related deaths worldwide. This is due to its asymptomatic nature or mild nonspecific symptoms. Most patients are diagnosed after appearance of prominent symptoms, and tumors are frequently accompanied by severe infiltration. Therefore, molecular biomarkers for the prognosis of early-stage esophageal cancer are desired. In this study, we examined the prognostic potential of lipase H (LIPH), a recently reported biomarker for lung adenocarcinoma and squamous carcinoma. We found that LIPH mRNA is also frequently upregulated in esophageal adenocarcinoma. Immunohistochemical analysis confirmed LIPH protein expression in various esophageal tumor tissue sections. Interestingly, higher expression of LIPH in esophageal adenocarcinoma showed a positive correlation with longer survival of patients. Our data suggest that LIPH may have prognostic value for esophageal cancer.

References

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Mar 30, 2010·Current Opinion in Genetics & Development·Pierre Lao-SirieixRebecca C Fitzgerald
Jul 14, 2010·Gastroenterology·Christopher J PetersUNKNOWN Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group
Jan 19, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Harry H YoonFrank A Sinicrope
Jan 25, 2013·Cell Cycle·Lorenzo GalluzziGuido Kroemer
Sep 17, 2013·World Journal of Gastroenterology : WJG·Yuwei Zhang
Jan 2, 2014·Biochemical and Biophysical Research Communications·Yasuhiro SekiAkira Kurisaki
Aug 16, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Meizi CuiChao Niu

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Citations

Jul 4, 2020·Journal of Cellular and Molecular Medicine·Yixiao ZhangCaigang Liu
Jul 16, 2021·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Bruno César FeltesMárcio Dorn

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