Lipase-Triggered Water-Responsive "Pandora's Box" for Cancer Therapy: Toward Induced Neighboring Effect and Enhanced Drug Penetration

Advanced Materials
Cheng WangHong Yuan

Abstract

Insufficient drug release as well as poor drug penetration are major obstacles for effective nanoparticles (NPs)-based cancer therapy. Herein, the high aqueous instability of amorphous calcium carbonate (ACC) is employed to construct doxorubicin (DOX) preloaded and monostearin (MS) coated "Pandora's box" (MS/ACC-DOX) NPs for lipase-triggered water-responsive drug release in lipase-overexpressed tumor tissue to induce a neighboring effect and enhance drug penetration. MS as a solid lipid can prevent potential drug leakage of ACC-DOX NPs during the circulatory process, while it can be readily be disintegrated in lipase-overexpressed SKOV3 cells to expose the ACC-DOX core. The high aqueous instability of ACC will lead to burst release of the encapsulated DOX to induce apoptosis and cytotoxicity to kill the tumor cells. The liberated NPs from the dead or dying cells continue to respond to the ubiquitous aqueous environment to sufficiently release DOX once unpacked, like the "Pandora's box", leading to severe cytotoxicity to neighboring cells (neighboring effect). Moreover, the continuously released free DOX molecules can readily diffused through the tumor extracellular matrix to enhance drug penetration to deep tumor tissue. Both e...Continue Reading

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Citations

Aug 28, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Ling-Xin MengHui-Yun Wang
Nov 30, 2018·Technology in Cancer Research & Treatment·Jinxing GuoYuanhang Zhou
Feb 27, 2019·Expert Opinion on Drug Delivery·Solmaz Maleki DizajFarzaneh Lotfipour
Jun 9, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jingwei ZhangJieyuan Zhang
Aug 2, 2019·Advanced Healthcare Materials·Cheng WangHong Yuan
Feb 15, 2020·The Journal of International Medical Research·Xiaojun SunGuobiao Yang
Feb 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yejin ZhuXiaotang Wang
Oct 13, 2019·Biomedizinische Technik. Biomedical Engineering·Weifan XuYifan Kang
Aug 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Meng WangWei R Chen
Nov 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min LiZiwei Jing
Aug 28, 2020·Frontiers in Chemistry·Mengqian LiQi Shuai
Jul 2, 2020·International Journal of Nanomedicine·Cheng WangHong Yuan
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Dec 7, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shan TaoHong Yuan
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Jul 8, 2019·ACS Biomaterials Science & Engineering·Chenxu ZhangYongjian Wang

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