Lipid absorption and intestinal lipoprotein formation

Australian and New Zealand Journal of Medicine
P H Green, J W Riley

Abstract

Lipid absorption is a complex process which involves coordinated gastric, intestinal, biliary and pancreatic function. Emulsification of dietary lipid occurs in the stomach and upper intestine where a series of enzymic events also occur. Phospholipids are digested by phospholipases. Colipase anchors lipase to the emulsion surface overcoming the interfering effect of bile salts. The products of lipolysis, monoglycerides and fatty acids, are removed from the emulsion surface by bile salts in the form of mixed micelles which transport lipid digestive products across the unstirred water layer to the epithelial cell. Within the intestinal epithelial cell a series of synthetic events occur resulting in the formation of chylomicrons and very low density lipoprotein (VLDL). Chylomicrons consists of an oily core of triglyceride surrounded by a membrane of phospholipids, free cholesterol and apoproteins which maintain the solubility of the particle in plasma. Chylomicrons from both experimental animals and man have specific apoproteins associated with them. These proteins include apoA-I, the major protein of plasma high density lipoproteins. During chylomicron metabolism, apoA-I and phospholipid from the chylomicron surface contribute to...Continue Reading

References

May 13, 1976·The New England Journal of Medicine·P L RayfordJ C Thompson
Aug 19, 1978·Lancet·E J SchaeferW C Blackwelder
Sep 1, 1976·The Journal of Clinical Investigation·R L HamiltonR J Havel
Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R M Glickman, P H Green
Feb 1, 1978·The Journal of Clinical Investigation·P H GreenR M Glickman
Mar 1, 1978·The Journal of Clinical Investigation·M F ReardonP J Nestel
Nov 30, 1978·The New England Journal of Medicine·A R Tall, D M Small
Dec 28, 1978·The New England Journal of Medicine·R M GlickmanA Tall
Jul 1, 1979·The Journal of Clinical Investigation·P H GreenA R Tall
Oct 1, 1979·The Journal of Clinical Investigation·A R TallJ W Riley
May 1, 1975·The Journal of Clinical Investigation·M HamoshR O Scow
Feb 26, 1979·Biochimica Et Biophysica Acta·B Sternby, B Borgström
Apr 13, 1979·Science·J S Patton, M C Carey
Nov 1, 1979·The Journal of Clinical Investigation·L BläckbergT Olivecrona
Jun 16, 1977·Biochimica Et Biophysica Acta·H P HauriB Hadorn
Aug 1, 1977·Life Sciences·G J BagbyJ A Spitzer
Sep 1, 1976·The Journal of Clinical Investigation·R K Ockner, J A Manning
Feb 1, 1975·The Journal of Physiology·J N Hunt, D F Stubbs
Oct 1, 1972·Archives of Internal Medicine·D M SmallR N Redinger
Dec 1, 1972·The Journal of Clinical Investigation·F A Wilson, J M Dietschy
Jan 1, 1973·The Journal of Clinical Investigation·M Hamosh, R O Scow
Aug 1, 1973·European Journal of Biochemistry·B Borgström, C Erlanson
Jan 15, 1974·Biochemical Pharmacology·K TakashimaS Takeyama
Apr 24, 1968·Biochimica Et Biophysica Acta·G H de HaasL L van Deenen
Oct 1, 1971·The Journal of Clinical Investigation·G N TytgatD R Saunders
Jan 1, 1967·Annual Review of Medicine·A F Hofmann, D M Small
Mar 1, 1970·The Journal of Clinical Investigation·T G Redgrave
Oct 1, 1965·The Journal of Clinical Investigation·D B Zilversmit
Jul 1, 1967·The Journal of Cell Biology·R R CardellK R Porter
Apr 4, 1967·Biochimica Et Biophysica Acta·S A HyunC R Treadwell
Apr 1, 1980·The Journal of Clinical Investigation·P H GreenE Quinet
Mar 1, 1980·The Journal of Clinical Investigation·F ShelburneS Quarfordt
Oct 1, 1962·The Journal of Clinical Investigation·P J NestelA Bezman

❮ Previous
Next ❯

Citations

Jul 11, 2001·Trends in Endocrinology and Metabolism : TEM·A StahlH F Lodish
Oct 23, 2009·Lipids in Health and Disease·Susan GallowayJohn C L Mamo
Jul 14, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jie ChengFrank J Gonzalez
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·D HirschH F Lodish
Oct 13, 2011·Biochimica Et Biophysica Acta·Xiaoyue Pan, M Mahmood Hussain
Oct 13, 1999·Molecular Cell·A StahlH F Lodish
Apr 15, 1997·Annals of the New York Academy of Sciences·M TamuraN Katsuta
Sep 1, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wendell J LuPatrick Tso
Mar 29, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wendell J LuPatrick Tso
Jun 22, 2014·Current Cardiology Reports·Alan A HennessyCatherine Stanton
Dec 1, 1983·British Journal of Haematology·G ObergP Venge
May 20, 1996·Biochimica Et Biophysica Acta·M M HussainA Bakillah
Jul 1, 1990·La Revue de médecine interne·G GayR Infante

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Medicine
J W Riley, R M Glickman
The Annals of Pharmacotherapy
Darego O Maclayton, Angie Eaton-Maxwell
© 2021 Meta ULC. All rights reserved