Lipid Accumulation Product and Hypertension Related to Stroke: a 9.2-Year Prospective Study Among Mongolians in China

Journal of Atherosclerosis and Thrombosis
Chongke ZhongYonghong Zhang

Abstract

We aimed to assess the relationship between lipid accumulation product (LAP) and stroke incidence and whether increased LAP would further enlarge the risk of stroke in participants with hypertension in an Inner Mongolian population of China. Based on the baseline survey conducted in 2002-2003, a prospective cohort study was conducted among 2547 Mongolian people from Inner Mongolia, China. LAP was calculated by waist circumference (WC) and triglyceride (TG) concentration for men and women, respectively. Cox proportional hazards models and receiver operating characteristic (ROC) curves were used to evaluate the associations between LAP, hypertension, and stroke incidence. During the follow-up period, a total of 121 stroke events were observed. Participants with higher LAP were associated with higher risk of stroke [adjusted hazard ratio (HR), 1.67; 95% confidence interval (CI), 1.08-2.58] than the participants in the lower LAP group. However, no significant dose-response relationship was detected between LAP levels and risk of stroke (P-trend=0.103). The Kaplan-Meier curves showed that hypertensives with high LAP had highest cumulative stroke incidence rate (log-rank P <0.001). The multivariate-adjusted HRs (95% CIs) of stroke fo...Continue Reading

References

Nov 1, 1993·Circulation·D PerloffB Z Morgenstern
Apr 5, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazumasa YamagishiTakashi Shimamoto
Nov 5, 2003·The American Journal of Clinical Nutrition·Henry S Kahn, Rodolfo Valdez
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Apr 9, 2004·The Proceedings of the Nutrition Society·Christine M Williams
Jun 23, 2004·Lancet Neurology·Ruth BonitaFrank Yatsu
Sep 16, 2005·The New England Journal of Medicine·Jiang HePaul K Whelton
Oct 12, 2005·Statistics in Medicine·Patrick RoystonWilli Sauerbrei
Oct 19, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S CzernichowJ-M Oppert
Mar 22, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Pierre DesprésPaul Poirier
Aug 30, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Hongmei LiYonghong Zhang
Nov 14, 2008·The New England Journal of Medicine·T PischonE Riboli
Aug 7, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Mohsen Ibrahim
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
May 13, 2010·Lipids in Health and Disease·Mohammadreza BozorgmaneshFereidoun Azizi
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Tracey McLaughlinFahim Abbasi
Apr 21, 2012·Stroke; a Journal of Cerebral Circulation·Haakon LindekleivEllisiv B Mathiesen
Apr 23, 2013·Journal of Atherosclerosis and Thrombosis·Mitsuyoshi TakaharaIichiro Shimomura
Jul 25, 2013·Stroke; a Journal of Cerebral Circulation·Tian XuYonghong Zhang
Sep 13, 2013·Journal of Atherosclerosis and Thrombosis·Mitsuyoshi TakaharaIichiro Shimomura
Nov 9, 2014·European Journal of Preventive Cardiology·Farhad HosseinpanahFereidoun Azizi
Sep 1, 2015·Journal of Endocrinological Investigation·N MotamedF Zamani

❮ Previous
Next ❯

Citations

Nov 10, 2017·Journal of Atherosclerosis and Thrombosis·Shinichi WadaUNKNOWN Japan Statin Treatment Against Recurrent Stroke (J-STARS) Echo Study Collaborators
Mar 16, 2019·Journal of Cardiovascular Development and Disease·Hung Nguyen NgocWichai Aekplakorn
Feb 15, 2017·Gastroenterology Research and Practice·Yuan-Lung ChengShou-Dong Lee
Sep 20, 2017·Journal of Atherosclerosis and Thrombosis·Naohisa HosomiUNKNOWN J-STARS collaborators
Jul 26, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Samon Henrique NunesMaria Luiza Garcia Rosa
Aug 17, 2021·Revista Portuguesa De Cardiologia·Samon Henrique NunesMaria Luiza Garcia Rosa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.