PMID: 696475Jan 1, 1978Paper

Lipid and fatty acid composition of human cerebral myelin during development

Advances in Experimental Medicine and Biology
L Svennerholm, M T Vanier

Abstract

A development study of major lipid fatty acids in human brain myelin was undertaken and compared to those in cerebral white matter of the same region. The myelin was isolated from 23 subjects at ages from newborn to old age. The proportions of cholesterol and galactolipids increased in myelin during the first 6 months of age and up to 2 years of age in cerebral white matter. During the same periods the individual phospholipids also showed marked variations. Serine phosphoglycerides and especially sphingomyelins increased, and choline phosphoglycerides decreased. The fatty acid patterns of ethanolamine phosphoglycerides (EPG) and sphingomyelins underwent the largest maturation changes. The proportions of saturated fatty acids in EPG diminished rapidly with a corresponding increase of monoenoic acids. Fatty acids of the linoleic acid series showed a peak between 4 months and 12 months of age, and then their proportion slowly diminished to old age. The fatty acid changes in serine phosphoglycerides were much less pronounced than in EPG but of similar type. In sphingomyelin the proportion of saturated long-chain fatty acids diminished while the proportion of monoenoic acids increased--this increase continued at least to the age of ...Continue Reading

Citations

Dec 27, 2016·Journal of Magnetic Resonance Imaging : JMRI·Jennifer E SounJack Grinband
Jan 1, 1993·Critical Reviews in Clinical Laboratory Sciences·K A Williams, C M Deber
Mar 14, 2001·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·C H Vite, J C McGowan
Dec 1, 1985·Archives internationales de physiologie et de biochimie·D Sappey MarinierJ Delmau
Mar 1, 1997·Journal of Neuroscience Methods·E Miot-NoiraultA Le Pape
Mar 29, 2001·Progress in Lipid Research·N Nagan, R A Zoeller
Mar 5, 2004·Chemistry and Physics of Lipids·M Cecilia Yappert, Douglas Borchman
Apr 1, 1991·Clinical Biochemistry·C M Deber, S J Reynolds

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