PMID: 3746462Jul 1, 1986Paper

Lipid and fatty acid composition of organs from copper-deficient mice

The Journal of Nutrition
S C CunnaneJoseph R Prohaska

Abstract

Experiments were conducted to study the total lipid and fatty acid composition of liver, kidney, brain and heart of 7-wk-old male C57BL mice. Dietary copper deficiency was initiated at birth by feeding dams a purified diet containing 0.5 mg/kg copper. Offspring were fed the copper-deficient diet 4 wk postweaning. Control dams and offspring were fed the same diet but with added copper in the drinking water, 20 mg/L. Compared with controls the copper-deficient mice exhibited hepatomegaly, cardiac hypertrophy and a 4% reduction in brain weight as well as low ceruloplasmin activity (0.5% of control). Total phospholipid concentration in liver and kidney and total triacylglycerol concentration in kidney was lower in copper-deficient mice compared to concentrations measured in liver and kidney of control mice. The major change in essential fatty acid composition in the copper-deficient mice which was consistent between organs and lipid classes was a significantly lower proportion and absolute amount of dihomo-gamma-linolenic acid. Other changes in fatty acid composition were variable.

Citations

Jan 1, 1995·Archiv für Tierernährung·S HartmannM Kirchgessner
Jan 1, 1989·Biological Trace Element Research·S C CunnaneC G Lewis
Jan 1, 1992·Reproductive Toxicology·D S Arce, C L Keen
Sep 1, 1990·The Journal of Nutritional Biochemistry·J R Prohaska
Aug 11, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ella N SmitE Rudy Boersma

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