Abstract
Potentially modifiable biomarkers may influence the decline in estimated GFR (eGFR), but few data are currently available in type 2 diabetic adults. We studied 516 women with type 2 diabetes in the Nurses' Health Study with data on lipid and inflammatory biomarkers from plasma collected in 1989 and plasma creatinine in samples collected in 1989 and 2000. An estimated GFR decline of >or=25% over 11 years was the outcome of interest. Comparing the highest with the lowest quartile, soluble tumour necrosis factor receptor 2 (sTNFR-2) was independently associated with an eGFR decline of >or=25% (multivariate OR 5.81; 95% CI 2.90-11.65); this association was stronger in obese women (OR 16.76; 95% CI 4.69-59.90 for BMI >or=30 kg/m(2); OR 2.78, 95% CI 1.12-6.89 for BMI <30 kg/m(2); p for interaction = 0.02). No lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, non-HDL-cholesterol, triacylglycerols, lipoprotein(a), or apolipoprotein B) or other markers of inflammation (C-reactive protein, fibrinogen, E-selectin, intracellular cell adhesion molecule 1, leptin or adiponectin) were significantly associated with eGFR decline after multivariable adjustment. Elevated sTNFR-2 levels may be an important and potentially modifiable ris...Continue Reading
References
Jul 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K A Nath
Feb 21, 2002·Circulation·Patrizia ZiccardiDario Giugliano
Nov 13, 2002·Kidney International·Mark J SarnakAndrew S Levey
Dec 8, 2004·Journal of the American Society of Nephrology : JASN·Linda FriedAnne Newman
Apr 21, 2005·Kidney International·Sarah B KhanCharles D Pusey
May 28, 2005·Diabetes Care·Iris ShaiFrank B Hu
Jun 16, 2005·Kidney International·Marcello TonelliUNKNOWN Cholesterol and Recurrent Events (CARE) Trial Investigators
Jan 13, 2006·Kidney International·J LinG C Curhan
May 30, 2006·Diabetes·Ravi RetnakaranUNKNOWN UKPDS Study Group
Jun 9, 2006·The New England Journal of Medicine·Lesley A StevensAndrew S Levey
Jun 26, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Tao YangGlenda C Gobe
Aug 7, 2007·The American Journal of Medicine·Aruna D PradhanPaul M Ridker
Apr 10, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Julie Lin, Gary C Curhan
Apr 29, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Meredith C FosterCaroline S Fox
Citations
Jul 26, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ko HanaiYasuhiko Iwamoto
Jan 24, 2012·Journal of the American Society of Nephrology : JASN·Monika A NiewczasAndrzej S Krolewski
Aug 13, 2010·The American Journal of Clinical Nutrition·Julie LinWilliam McClellan
May 10, 2013·Current Diabetes Reports·Tomohito Gohda, Yasuhiko Tomino
Sep 24, 2015·Kidney International·Meda E PavkovAndrzej S Krolewski
Apr 14, 2016·Journal of Diabetes and Its Complications·Nicolás Gómez-BanoyIsmena Mockus
Feb 4, 2011·Diabetes Research and Clinical Practice·Itsuko MiyazawaHiroshi Maegawa
Jun 1, 2014·Diabetes Care·Carol ForsblomUNKNOWN FinnDiane Study Group
Mar 11, 2015·Current Hypertension Reports·Divya HariharanHolly Kramer
Oct 3, 2014·Endocrine·Federica BaruttaGabriella Gruden
Apr 12, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hsin-Fang ChungMeng-Chuan Huang
Jan 15, 2015·Journal of Diabetes Research·I-Th LampropoulouG Efstratiadis
Sep 27, 2014·PloS One·Daniel MedenwaldKarl Werdan
Nov 8, 2016·Advances in Medicine·Mohammad Hossein RouhaniLeila Azadbakht
May 31, 2018·Postgraduate Medicine·Angelika BazylukEdyta Zbroch
Feb 6, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Jørgen ScheiToralf Melsom
May 4, 2011·Nature Reviews. Nephrology·Juan F Navarro-GonzálezJavier García-Pérez
Jun 18, 2019·Diabetes/metabolism Research and Reviews·Xiaoqi YeJinbo Hu
Oct 6, 2016·Diabetes Care·Giuseppina T RussoUNKNOWN AMD-Annals Study Group
Mar 1, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Matthew W WongPerminder S Sachdev
Aug 2, 2017·Clinical Science·Greg H Tesch
Mar 11, 2020·Diabetologia·Sunny S SinghMandy van Hoek
Dec 10, 2019·Endocrine·Dongsheng ChengNiansong Wang
Apr 25, 2020·Journal of Nephrology·Giuseppina RussoSalvatore De Cosmo
Nov 28, 2018·Journal of Nephrology·Francesca ViazziRoberto Pontremoli
Dec 22, 2016·Diabetes Care·Pierre-Jean SaulnierUNKNOWN SURDIAGENE Study Group
Nov 14, 2020·Scientific Reports·Julia KerschbaumGert Mayer
Apr 13, 2021·Frontiers in Endocrinology·Xiaoyan RenZhaoli Yan
Jul 21, 2021·Scientific Reports·Oyunchimeg BuyadaaJonathan E Shaw
Oct 17, 2020·Journal of Diabetes Research·Chuan WangLi Chen