Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Francesco Mainini, Michael R Eccles

Abstract

RNA interference (RNAi) uses small interfering RNAs (siRNAs) to mediate gene-silencing in cells and represents an emerging strategy for cancer therapy. Successful RNAi-mediated gene silencing requires overcoming multiple physiological barriers to achieve efficient delivery of siRNAs into cells in vivo, including into tumor and/or host cells in the tumor micro-environment (TME). Consequently, lipid and polymer-based nanoparticle siRNA delivery systems have been developed to surmount these physiological barriers. In this article, we review the strategies that have been developed to facilitate siRNA survival in the circulatory system, siRNA movement from the blood into tissues and the TME, targeted siRNA delivery to the tumor or specific cell types, cellular uptake, and escape from endosomal degradation. We also discuss the use of various types of lipid and polymer-based carriers for cancer therapy, including a section on anti-tumor nanovaccines enhanced by siRNAs. Finally, we review current and recent clinical trials using NPs loaded with siRNAs for cancer therapy. The siRNA cancer therapeutics field is rapidly evolving, and it is conceivable that precision cancer therapy could, in the relatively near future, benefit from the com...Continue Reading

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Citations

Oct 11, 2020·Pharmaceuticals·Muhammad Imran SajidRakesh Kumar Tiwari
Feb 18, 2021·Nucleic Acid Therapeutics·Sumit GangopadhyayKiran R Gore
Jun 22, 2021·Frontiers in Bioengineering and Biotechnology·Giulio GiustariniGiulia Adriani
Jul 20, 2021·Chemical Reviews·Yuebao ZhangYizhou Dong
Aug 10, 2021·Molecular Aspects of Medicine·Alysia CoxEun Ji Chung
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu HuangQuanshun Li
Dec 7, 2021·Nanoscale Research Letters·Nicole Remaliah Samantha SibuyiMervin Meyer

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