journal cover

Lipid Assemblies at the Crossroads of Aging, Proteostasis, and Neurodegeneration

Trends in Cell Biology

Dec 25, 2019

Noa Roitenberg, Ehud Cohen

Get paper from

Abstract

The proteostasis network (PN) is a nexus of mechanisms that act in concert to maintain the integrity of the proteome. Efficiency of the PN declines with age, resulting in the accumulation of misfolded proteins, and in some cases in the development of neurodegenerative disorders. Thus, m...read more

Mentioned in this Paper

Aging
Lipids
Nerve Degeneration
Neurodegenerative Disorders
Biological Neural Networks
Structure
Proteome
Behavior Research, Direct
Compound (Substance)
Proteostasis Deficiencies
5
1
9
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Neural Networks

Here is the latest research on physiological and in silico networks and circuits implicated in the nervous system.

Cell Aging

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Neurodegeneration: Progranulin & Lipids

Progranulin is a secreted growth factor involved in inflammation, wound healing, cancer, and for its neurotrophic properties. Along with lipids (fats), these molcules are associated with neurodegenerative processes. Here are the latest discoveries pertaining to these molecules and neurodegeneration.

Proteostasis

Proteostasis is the concept that there are competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking and degradation of proteins present within and outside the cell. Mechanisms by which proteostasis is ensured include regulated protein translation, chaperone assisted protein folding and protein degradation pathways. Adjusting each of these mechanisms to the demand for proteins is essential to maintain all cellular functions relying on a correctly folded proteome.

© 2019 Meta ULC. All rights reserved

Lipid Assemblies at the Crossroads of Aging, Proteostasis, and Neurodegeneration

Trends in Cell Biology

Dec 25, 2019

Noa Roitenberg, Ehud Cohen

PMID: 31669295

DOI: 10.1016/j.tcb.2019.09.003

Abstract

The proteostasis network (PN) is a nexus of mechanisms that act in concert to maintain the integrity of the proteome. Efficiency of the PN declines with age, resulting in the accumulation of misfolded proteins, and in some cases in the development of neurodegenerative disorders. Thus, m...read more

Mentioned in this Paper

Aging
Lipids
Nerve Degeneration
Neurodegenerative Disorders
Biological Neural Networks
5
1
9
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Get paper from

/papers/lipid-assemblies-at-the-crossroads-of-aging/31669295