Nov 2, 2019

Lipid Assemblies at the Crossroads of Aging, Proteostasis, and Neurodegeneration

Trends in Cell Biology
Noa Roitenberg, Ehud Cohen

Abstract

The proteostasis network (PN) is a nexus of mechanisms that act in concert to maintain the integrity of the proteome. Efficiency of the PN declines with age, resulting in the accumulation of misfolded proteins, and in some cases in the development of neurodegenerative disorders. Thus, maintaining an active and efficient PN through the late stages of life could delay or prevent neurodegeneration. Indeed, altering the activity of aging-regulating pathways protects model organisms from neurodegeneration-linked toxic protein aggregation. Here, we delineate evidence that the formation and integrity of lipid assemblies are affected by aging-regulating pathways, and describe the roles of these structures in proteostasis maintenance. We also highlight future research directions and discuss the possibility that compounds which modulate lipid assemblies could be used for the treatment of neurodegenerative disorders.

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  • Current Opinion in Clinical Nutrition and Metabolic Care
    Jorge MontesinosEstela Area-Gomez
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Mentioned in this Paper

Biological Neural Networks
Nerve Degeneration
Proteome
Behavior Research, Direct
Structure
Aging
Lipids
Compound (Substance)
Neurodegenerative Disorders
Regulation of Signaling Pathway

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