PMID: 8443404Jan 1, 1993Paper

Lipid-associated sialic acid levels in human breast cyst fluids

Breast Cancer Research and Treatment
F MannelloG Gazzanelli

Abstract

Benign mammary gross cystic disease is the most common breast lesion. Women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal female population. Sialic acid has drawn considerable interest because of carbohydrate aberrations in malignant cells. The current investigation determined the concentrations of lipid-associated sialic acid (LASA) in 62 breast cyst fluids and sera. Data analyses show a significant increase in the mean values of LASA in metabolically active apocrine cysts when compared to the cysts with Na+/K+ > 3 (flattened cysts) (p < 0.001). The greater LASA levels in cyst fluids with lower intracystic Na+/K+ ratios could represent an altered expression of biosynthetic activity of the surrounding apocrine cell surface sialoglycolipid metabolism, providing a possible explanation of why women with apocrine cysts may be at greater cancer risk and being useful in further studies on functional stage changes in the cysts and their relationship to breast cancer.

References

Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S CiattoA Iossa
Jan 1, 1989·Critical Reviews in Oncology/hematology·J A Alhadeff
Jul 1, 1988·The British Journal of Surgery·S R Ebbs, T Bates
Jan 1, 1986·Breast Cancer Research and Treatment·D P Rose
Oct 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·S BiagioniR Troccoli
Nov 1, 1982·Cancer·A M DnistrianC C Stock

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Citations

Jan 1, 1996·Breast Cancer Research and Treatment·F MannelloG Gazzanelli
Dec 7, 2005·Breast Cancer Research and Treatment·Ferdinando MannelloStefano Papa
Mar 2, 1995·Cancer Letters·F MannelloG Gazzanelli
Jan 30, 1994·Cancer Letters·F MannelloG Gazzanelli
May 23, 1998·Breast Cancer Research and Treatment·M MalatestaG Gazzanelli
Jan 2, 1996·Cancer Letters·F MannelloG Gazzanelli

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