Lipid bilayer discs and banded tubules: photoinduced lipid sorting in ternary mixtures

Journal of the American Chemical Society
Jing YuanLinda S Hirst

Abstract

The self-assembly of biological amphiphiles has proved a fascinating topic in recent years, the hollow cylindrical lipid tubule morphology being of particular interest due to its potential applications in "soft" microtechnologies. Lateral coexistence of liquid-ordered (lo) and liquid-disordered (ld) phases, which may resemble raft formation in cell membranes, was investigated in lipid tubules, prepared from 1,2-dioleoyl-sn-glycero-3-phosphocholine, egg-sphingomyelin, and cholesterol. Fluorescence microscopy shows that the appearance of micrometer-scale lo domains in the lipid tubule is not an intrinsic phase behavior of the system but a consequence of photoinduced lipid peroxidation. Most interestingly, new photoinduced bilayer structures: lipid discs, essentially stable flattened liposomes, were observed for the first time in a model membrane system. This investigation not only aids in our understanding of lipid sorting phenomena in cell membranes but also demonstrates how control of this process may provide a route to the generation of new, functional structures.

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Citations

Mar 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Benoit SorrePatricia Bassereau
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael HeinrichTobias Baumgart
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Oct 3, 2009·Biochimica Et Biophysica Acta·Marie-Cécile GiocondiChristian Le Grimellec

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