Lipid Cell Biology: A Focus on Lipids in Cell Division

Annual Review of Biochemistry
Elisabeth M StorckUlrike S Eggert

Abstract

Cells depend on hugely diverse lipidomes for many functions. The actions and structural integrity of the plasma membrane and most organelles also critically depend on membranes and their lipid components. Despite the biological importance of lipids, our understanding of lipid engagement, especially the roles of lipid hydrophobic alkyl side chains, in key cellular processes is still developing. Emerging research has begun to dissect the importance of lipids in intricate events such as cell division. This review discusses how these structurally diverse biomolecules are spatially and temporally regulated during cell division, with a focus on cytokinesis. We analyze how lipids facilitate changes in cellular morphology during division and how they participate in key signaling events. We identify which cytokinesis proteins are associated with membranes, suggesting lipid interactions. More broadly, we highlight key unaddressed questions in lipid cell biology and techniques, including mass spectrometry, advanced imaging, and chemical biology, which will help us gain insights into the functional roles of lipids.

References

Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S MadaniN A Khan
Oct 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nihal Altan-BonnetJennifer Lippincott-Schwartz
Jun 16, 2004·The Journal of Cell Biology·Alejandra TomasStephen E Moss
Sep 7, 2004·Biophysical Journal·Fitzroy J ByfieldIrena Levitan
Sep 24, 2004·Experimental Cell Research·Carlos FernándezMiguel A Lasunción
Aug 9, 2005·Current Biology : CB·Seth J FieldLewis C Cantley
Sep 16, 2005·The Journal of Biological Chemistry·Kazuo EmotoMasato Umeda
Dec 2, 2005·Nature·Harvey T McMahon, Jennifer L Gallop
Mar 10, 2006·Molecular Biology of the Cell·Chengjing ZhouRichard A Kahn
Jun 8, 2006·Annual Review of Biochemistry·Ulrike S EggertChristine M Field
Sep 5, 2006·Current Biology : CB·Ilektra KourantiArnaud Echard
Oct 10, 2006·The Journal of Biological Chemistry·Xiao-Wei ChenAlan R Saltiel
Nov 1, 2006·The Journal of Biological Chemistry·Krishnakumar KizhatilVann Bennett
Nov 23, 2006·Nature Cell Biology·Annika WolfMechthild Hatzfeld
Jun 9, 2007·Science·Jez G Carlton, Juan Martin-Serrano
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Jul 8, 2008·Nature Cell Biology·Adrian T SaurinPeter J Parker
Sep 23, 2008·Current Biology : CB·Edith Szafer-GlusmanMargaret T Fuller
Sep 23, 2008·Developmental Cell·Teijo PellinenJohanna Ivaska
Oct 28, 2008·Trends in Biotechnology·Matej OresicAntonio Vidal-Puig
Dec 4, 2008·Journal of Lipid Research·Robert C MurphyRobert M Barkley
Dec 23, 2008·Journal of Lipid Research·Eoin FahyEdward A Dennis
Feb 24, 2009·Nature Reviews. Molecular Cell Biology·Stephan GüttingerUlrike Kutay
Dec 18, 2009·ACS Chemical Biology·G Ekin Atilla-GokcumenUlrike S Eggert
Mar 9, 2010·Nature Cell Biology·Antonia P SagonaHarald Stenmark
Mar 17, 2010·Cell Research·Jianhua ZhangJiarui Wu
Mar 23, 2010·Nature·Thomas Wollert, James H Hurley

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Citations

Jul 6, 2018·Molecular Omics·Marie SaitouGunes Ekin Atilla-Gokcumen
May 18, 2019·Proteomics·Cagakan ÖzbalciUlrike S Eggert
Jun 19, 2019·Journal of Cell Science·MariaSanta C Mangione, Kathleen L Gould
Apr 18, 2019·Beilstein Journal of Organic Chemistry·Karen J Ardila-FierroCarsten Bolm
Feb 9, 2020·Nature Reviews. Molecular Cell Biology·Jeremy G CarltonUlrike S Eggert
Aug 26, 2020·Metabolites·Alec Millner, G Ekin Atilla-Gokcumen
Jun 14, 2019·Frontiers in Immunology·Philipp M HagemannZane Orinska
Jan 9, 2019·Frontiers in Cell and Developmental Biology·Roger J Morris
Nov 28, 2020·The Science of the Total Environment·Hoa Thanh NguyenHisato Iwata
Jul 28, 2020·Trends in Analytical Chemistry : TRAC·Jianing Wang, Xianlin Han
Nov 18, 2020·The Journal of Membrane Biology·Susovan SarkarSudha Rajamani
Oct 14, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·R Ariel Igal, Débora I Sinner
May 18, 2019·Proteomics·Nasi LiGunes Ekin Atilla-Gokcumen
May 17, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Milada VítováSamuel Furse
Jul 9, 2021·Soft Matter·Sudipta Gupta, Rana Ashkar
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Silvia RadrezzaAlfonsina D'Amato

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Methods Mentioned

BETA
myristoylation
GTPase
GTPases
lipidation
ion mobility spectrometry
atomic force microscopy
super-resolution microscopy

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