PMID: 8842372Jun 1, 1996Paper

Lipid composition and fluidity in the jejunal brush-border membrane of spontaneously hypertensive rats. Effects on activities of membrane-bound proteins

Bioscience Reports
C M VázquezV Ruiz-Gutierrez


The lipid composition and fluidity of jejunal brush-border membrane vesicles (BBMV) have been studied in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats. The activities of both Na(+)-dependent D-glucose cotransport and Na(+)-H+ antiport have also been determined. A significant increase in the level of free cholesterol was observed in jejunal BBMV from SHR compared to WKY rats. Since phospholipid values did not change in either group of animals, a significant enhancement in the free cholesterol/phospholipid ratio was observed in SHR. A decrease in the levels of phosphatidylethanolamine together with an increase in the values of phosphatidylserine was observed in hypertensive rats. Although the content of phosphatidylcholine (PC) and sphingomyelin (SM) was not significantly altered in SHR, the ratio PC/SM significantly increased in these animals when compared to WKY rats. The major fatty acids present in bursh-border membranes prepared from SHR and WKY rats were palmitic (16:0), stearic (18:0), oleic (18:1, n-9) and linoleic (18:2, n-6), and the fatty acid composition was not modified by the hypertension. A decreased fluorescence polarization, i.e., increased membrane fluidity, was observed in SHR, ...Continue Reading


Dec 15, 1978·Biochimica Et Biophysica Acta·M Shinitzky, Y Barenholz
Apr 16, 1976·Biochimica Et Biophysica Acta·M Shinitzky, M Inbar
Nov 1, 1991·The American Journal of Physiology·L L Ng, J E Davies
Dec 1, 1991·Hypertension·A F DominiczakD F Bohr
Nov 1, 1991·American Journal of Hypertension·A B Weder
Dec 1, 1991·American Journal of Hypertension·A F Dominiczak, D F Bohr
Mar 1, 1990·Gastroenterology·S P Shirazi-BeecheyR B Beechey
Jul 31, 1990·Biochemical and Biophysical Research Communications·D J Bjorkman, E J Brigham
Oct 1, 1987·Journal of Hypertension·A M Heagerty, J D Ollerenshaw
Apr 1, 1989·Journal of Hypertension·R L Schmouder, A B Weder
Oct 1, 1989·Kidney International·G A MorduchowiczN Yanagawa
May 28, 1986·Biochimica Et Biophysica Acta·B Carrière, C Le Grimellec
Dec 1, 1986·British Journal of Pharmacology·A M HeagertyJ D Swales
Jan 1, 1971·Pflügers Archiv : European journal of physiology·R KinneE Kinne-Saffran
Jan 1, 1982·The Journal of Membrane Biology·G Schmalzing, P Kutschera
Feb 1, 1984·Journal of Hypertension·Y V Postnov, S N Orlov
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M A DevynckP Meyer
Sep 1, 1982·Clinical Science·S N Orlov, Y V Postnov
Jan 1, 1993·Journal of Hypertension·Y McLarenA F Dominiczak
May 1, 1993·Hypertension·D RosskopfW Siffert
Jan 1, 1964·Analytical Biochemistry·A DAHLQVIST

❮ Previous
Next ❯


Sep 14, 2007·Molecular Membrane Biology·Jesús PradesFrancisca Barceló

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.