Lipid composition and sensitivity of Prototheca wickerhamii to membrane-active antimicrobial agents.

Antimicrobial Agents and Chemotherapy
I J Sud, D S Feingold

Abstract

The lipid composition of Prototheca wickerhamii ATCC 16529 is presented and discussed in relation to the unique susceptibility of the organism to drugs of three membrane-active antimicrobial classes: the polyenes, the polymyxins, and the imidazoles. The presence of ergosterol in the neutral lipid fraction of the membrane is likely responsible for the exquisite susceptibility to amphotericin B. The presence of a large quantity of free fatty acids in the membrane appears responsible for imidazole susceptibility. The membrane determinants of polymyxin B susceptibility are less well defined.

References

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Citations

Sep 1, 1982·Antimicrobial Agents and Chemotherapy·I J Sud, D S Feingold
Apr 13, 2007·Clinical Microbiology Reviews·Cornelia Lass-Flörl, Astrid Mayr
Nov 5, 2016·International Journal of Dermatology·Chul Hyun YunJoo Young Roh
Nov 16, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Linda TomasinsigMargherita Zanetti
Aug 12, 2009·International Journal of Systematic and Evolutionary Microbiology·Kazuo SatohKoichi Makimura
Jan 19, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·I RamírezJ C Pérez
Apr 11, 2021·Medical Mycology·Takahisa WatanabeMichiaki Masuda
Jun 1, 1981·The Journal of Investigative Dermatology·I J Sud, D S Feingold
Nov 19, 2020·Mycopathologia·Michiaki MasudaRui Kano

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