PMID: 9528675Apr 7, 1998Paper

Lipid composition changes induced by tamoxifen in a bacterial model system

Biochimica Et Biophysica Acta
C LuxoV M Madeira

Abstract

A putative relationship between growth impairment of Bacillus stearothermophilus by tamoxifen (TAM) and TAM-induced perturbation of the physical properties of bacterial membrane lipids has been observed. The supplementation of the growth medium with Ca2+ (a membrane stabilizer) partially relieves growth inhibition by TAM, allowing growth at TAM concentrations that fully impair growth in the basal medium. B. stearothermophilus modifies the membrane lipid composition in response to the addition of TAM to the growth medium and the response is sensitive to Ca2+. Changes in lipid composition are observed in the acyl chains and in the polar head groups of phospholipids. The physical effects of alteration in these lipids was studied by fluorescence polarization of DPH and DPH-PA. Polar lipid dispersions from TAM-adapted cells grown in a Ca2+ medium show a shift of Tm to higher temperatures and a significant increase of the structural order as compared to lipids from control cells, suggesting that TAM-induced lipid composition changes compensate for the destabilizing effects of the cytostatic on membrane organization. The polar lipids from cells grown in the basal medium containing tamoxifen are also altered, but these alterations do n...Continue Reading

References

Dec 15, 1978·Biochimica Et Biophysica Acta·M Shinitzky, Y Barenholz
Dec 20, 1979·Biochimica Et Biophysica Acta·P R Cullis, B de Kruijff
Aug 15, 1991·Archives of Biochemistry and Biophysics·A S JuradoV M Madeira
May 15, 1991·Biochemical and Biophysical Research Communications·J B CustódioV M Madeira
Jan 1, 1989·Annual Review of Biochemistry·J A Endicott, V Ling
Jun 1, 1989·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·O L Kon
Jun 30, 1987·Biochemical and Biophysical Research Communications·T McGrath, M S Center
Jan 1, 1988·Life Sciences·W G Wood, F Schroeder
Dec 17, 1985·Biochemical and Biophysical Research Communications·L C WrightC E Mountford
Jul 12, 1974·Biochimica Et Biophysica Acta·C W HaestL L Van Deenen
May 1, 1982·Journal of Bacteriology·J P Bohin, B Lubochinsky
Nov 17, 1980·Biochemical and Biophysical Research Communications·S B Farren, P R Cullis
Jul 6, 1981·Biochimica Et Biophysica Acta·A ChristianssonG Lindblom
Feb 23, 1994·Biochimica Et Biophysica Acta·M C Antunes-MadeiraV M Madeira
Jan 20, 1994·Biochemical Pharmacology·J D CroxtallR J Flower
Oct 29, 1996·Biochimica Et Biophysica Acta·F J Weber, J A de Bont
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Apr 1, 1965·Journal of Chromatography·H JACIN, A R MISHKIN
May 1, 1991·Applied and Environmental Microbiology·A InoueK Horikoshi
Aug 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C LuxoV M Madeira

❮ Previous
Next ❯

Citations

Aug 7, 2008·Applied Biochemistry and Biotechnology·João P MonteiroAmália S Jurado
Aug 14, 2003·Journal of Biochemical and Biophysical Methods·J T Trevors
Dec 3, 2002·Journal of Microbiological Methods·T J DenichJ T Trevors
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C LuxoV M Madeira
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J D MartinsV M C Madeira
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J P MonteiroV M C Madeira
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C LuxoM T Silva
Apr 22, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sandra M A SantosAmália S Jurado
Feb 12, 2020·Pharmaceutical Research·Uyen P N DaoTrang T Nguyen
Nov 27, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Patrick S Coppock, James T Kindt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.