PMID: 6794879Jan 1, 1981

Lipid composition of two types of chondrocytes in primary culture

Calcified Tissue International
M Le LousP Maroteaux


Chondrocytes from articular and growth plate cartilage were grown in primary culture. The lipid content, distribution into different types, as well as the fatty acid patterns of these lipids were compared when the cells had reached stationary phase and were synthesizing maximal amounts of proteoglycans. Numerous significant differences were observed, depending on the origin of the chondrocytes. In particular, growth plate chondrocytes showed increased dry weight, increased lipid content (phosphatides and triglycerides), and decreased cholesterol to phosphatide ratio when compared to articular chondrocytes; they also incorporated more of C18:1 and less C16:0 into their major lipid types. Whether these differences arise from specific metabolic regulation or are a consequence of chondrocyte organization in primary culture remains unclear.


Apr 18, 1975·Biochimica Et Biophysica Acta·S R SrinivasanP Dolan
May 1, 1976·The Proceedings of the Nutrition Society·K J Carpenter
Dec 28, 1972·Biochimica Et Biophysica Acta·O Vesterberg, R Eriksson
Mar 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·R L SEARCY, L M BERGQUIST


Jun 4, 2008·Journal of Pediatric Orthopedics·Hiroshi KitohNaoki Ishiguro
Oct 19, 2013·International Journal of Molecular Sciences·Amanda VillalvillaGabriel Herrero-Beaumont

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