Lipid-covered drug particles: combined action of dioctadecyldimethylammonium bromide and amphotericin B or miconazole

The Journal of Antimicrobial Chemotherapy
Nilton Lincopan, Ana Maria Carmona-Ribeiro

Abstract

Coverage of antifungal drug particles (miconazole and amphotericin B) with cationic lipid and evaluation of a synergistic action between lipid and drug. Miconazole and amphotericin B were mixed with cationic bilayer fragments (BF) of dioctadecyldimethylammonium bromide (DODAB) at extreme drug to lipid molar proportions (P). Light scattering for particle sizing and zeta-potential analysis evaluated effects of cationic lipid on drug particle size and charge. Colony counts evaluated viability of Candida spp. and Cryptococcus neoformans over a range of P. BF loading capacity for monomeric amphotericin B is 0.1 mM amphotericin B at 2 mM DODAB (P = 1:20). Above this low P, amphotericin B aggregates in the dispersion. At high P, addition of chaotropic K2HPO4 (0.2-2 mM) converts miconazole or amphotericin B aggregates into negatively charged particles with affinity for cationic lipid, which then surrounds each drug particle with a cationic layer. The combined in vitro action of lipid-covered drug particles against Candida and C. neoformans depends on P and interaction time. DODAB by itself kills C. neoformans and Candida at 2 and 2 to > 250 mg/L minimal fungicidal concentration (MFC). In combination, over the first hour, fungicidal act...Continue Reading

Citations

Jan 21, 2009·BMC Biotechnology·Nilton LincopanAna M Carmona-Ribeiro
May 9, 2008·Journal of Nanobiotechnology·Débora B Vieira, Ana M Carmona-Ribeiro
May 14, 2010·International Journal of Nanomedicine·Ana Maria Carmona-Ribeiro
Nov 21, 2007·Journal of Liposome Research·Ana Maria Carmona-Ribeiro
Sep 20, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Nilton LincopanAna M Carmona-Ribeiro
Jul 11, 2020·Biomimetics·Ana Maria Carmona-Ribeiro, Yunys Pérez-Betancourt
Nov 16, 2018·Drug Delivery and Translational Research·Prakash Kumar, Partha Pratim Bose
Jul 6, 2018·International Journal of Environmental Research and Public Health·Ana Maria Carmona-Ribeiro
Jun 29, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Letícia D MeloAna M Carmona-Ribeiro

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