PMID: 9552136Apr 29, 1998Paper

Lipid digestion in cystic fibrosis: comparison of conventional and high-lipase enzyme therapy using the mixed-triglyceride breath test

Journal of Pediatric Gastroenterology and Nutrition
K De BoeckY F Ghoos

Abstract

Fat maldigestion occurs in most patients with cystic fibrosis. Conventional pancreatic enzyme replacement therapy partially corrects this defect. In this study, the mixed-triglyceride breath test was used to evaluate whether high-lipase enzymes are equivalent to conventional enzymes in improving fat maldigestion in children with cystic fibrosis. Fat digestion was studied in 11 patients with a mean age of 10.5 years. The mean intake of conventional enzyme capsules a day was 19. Four 13C mixed-triglyceride tests were performed on separate days and in random order. One test was taken without enzyme substitution, one with three capsules of 8,000 FIP units Creon (pancreatinum, Kali-chemie Pharma, Hannover, Germany) and one with one capsule of 25,000 FIP units. The fourth test was made with 13C octanoic acid to study gastric emptying time. Without enzyme intake, the mean cumulative percentage of 13C dose exhaled after 6 hours was 7.2+/-3.7%. This increased to 14.4+/-4% with intake of conventional pancreatinum and to 14.3+/-5.1% with intake of high-lipase pancreatinum (p = 0.0008 for both; paired t-test). There was no difference between both treatments. Also, the time course of 13C exhalation measured by percentage of 13CO2 exhaled pe...Continue Reading

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Citations

Jul 8, 2011·The British Journal of Nutrition·Małgorzata BożekMonika Piłka
Jul 21, 2000·Isotopes in Environmental and Health Studies·K de MeerC Jakobs
Jun 29, 2001·Journal of Pediatric Gastroenterology and Nutrition·K van Dijk-van AalstG Veereman-Wauters
Aug 19, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Caterina AnaniaClaudio Chiesa
Mar 21, 2008·Biochemical and Biophysical Research Communications·Damien Yann ColinBrigitte Kerfelec
Apr 21, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·J Enrique Domínguez-MuñozMarta Iglesias-Rey
Apr 23, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Natalie van der HaakStamatiki Kritas
Feb 3, 2016·The American Journal of Medicine·Rohan MandaliyaSidney Cohen
Nov 24, 2016·The Cochrane Database of Systematic Reviews·Usha Rani Somaraju, Arturo Solis-Moya
Nov 30, 2006·Journal of Pediatric Gastroenterology and Nutrition·Christine SlaterLawrence T Weaver
Dec 7, 2005·Rapid Communications in Mass Spectrometry : RCM·Christine SlaterLawrence T Weaver
Aug 8, 2020·The Cochrane Database of Systematic Reviews·Usha Rani R Somaraju, Arturo Solis-Moya

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