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Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

bioRxiv

Aug 6, 2019

Julia MarschallingerTony Wyss-Coray

Abstract

Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report a striking buildup of lipid droplets in microglia with aging in mouse and huma...read more

Mentioned in this Paper

Lipid Droplet
Pathogenesis
Genes
Transcription, Genetic
Brain
Nerve Degeneration
Cytokine
Aging
Screening Generic
Inflammation
120
154
Paper Details
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Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

bioRxiv

Aug 6, 2019

Julia MarschallingerTony Wyss-Coray

DOI: 10.1101/722827

Abstract

Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report a striking buildup of lipid droplets in microglia with aging in mouse and huma...read more

Mentioned in this Paper

Lipid Droplet
Pathogenesis
Genes
Transcription, Genetic
Brain
Nerve Degeneration
Cytokine
Aging
Screening Generic
Inflammation
120
154

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Microglia: Health and Disease

Microglia are the resident macrophages of the central nervous system. Microglia-derived inflammatory neurotoxins play a principal role in the pathogenesis of several neurodegenerative disorders. Here is the latest research on the role of microglia in health and disease.

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Microglial activation in neuroinflammation: implications for the etiology of neurodegeneration

Neuro-degenerative DiseasesFebruary 4, 2012
Yoko S KanekoAkira Ota
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