Lipid droplet accumulation in cardiac muscle cells of the bat: potential auto-toxicity of the cardiac sympathetic innervation

The Anatomical Record
E A NunezM D Gershon


The previously described ability of reserpine and parachlorophenylalanine to induce the accumulation of lipid droplets in ventricular cardiac muscle cells of the bat was investigated. Lipid droplet accumulation was assessed qualitatively by light microscopy and quantitatively by morphometric analysis of electron micrographs. An hypothesis that the action of the drugs was an indirect one, mediated by the cardiac adrenergic innervation, was framed and tested. Lipid droplet accumulation occurred during a time of intense sympathetic activity, that of arousal from hibernation. The ability of the two drugs to produce the effect was antagonized by prior sympathetectomy with 6-hydroxy-dopamine. The effect was mimicked by administration of exogenous norepinephrine together with inhibitors of its catabolic enzymes, monoamine oxidase and catechol-o-methyl transferase. These observations are all consistent with the initial hypothesis and raise the possibility that endogenous norepinephrine in the cardiac sympathetic innervation might be, at least potentially, auto-toxic.


Apr 1, 1971·The Journal of Physiology·S Z Langer, M Vogt
Jul 1, 1972·British Journal of Pharmacology·A B Drakontide, M D Gershon
Nov 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A Alousi, N Weiner
Jan 1, 1971·Physiological Reviews·H EliasD E Schwartz
Sep 1, 1972·Journal of Applied Physiology·T J ReganP O Ettinger
Nov 1, 1969·British Journal of Pharmacology·S L Lightman, L L Iversen
May 1, 1965·Biochemical Pharmacology·S H SnyderM Zweig
Jul 25, 1958·The Journal of Biophysical and Biochemical Cytology·M L WATSON
Oct 1, 1963·The Journal of Physiology·C P LYMAN, R C O'BRIEN
Jul 1, 1964·American Heart Journal·V J FERRANSD G WEILBAECHER
Dec 1, 1950·The American Journal of Physiology·P O CHATFIELD, C P LYMAN

❮ Previous
Next ❯


Feb 1, 1994·Respiration Physiology·O Mathieu-CostelloJ M Szewczak
Jan 1, 1983·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M L FondaR W Cuddihee
Mar 23, 2021·Journal of Molecular Cell Biology·Yu-Cheng WangHao Ying

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.