Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Chloé JamatyJean-Marc Chauny

Abstract

To assess the evidence regarding the efficacy and safety of intravenous fat emulsion (IFE) in the management of poisoned patients. We performed a systematic review of the literature with no time or language restriction. The electronic databases were searched from their inception until June 1, 2009 (Medline, EMBASE, ISI web of science, Biological abstract, LILACS, ChemIndex, Toxnet, and Proquest). We also examined the references of identified articles and the gray literature. The target interventions eligible for inclusion were administration of any IFE before, during, or after poisoning in human or animals. All types of studies were reviewed. Eligibility for inclusion and study quality scores, based on criteria by Jadad and the STROBE statement, were evaluated by independent investigators. The primary outcome was mortality. Secondary outcomes included neurologic, hemodynamic, and electrocardiographic variables, as well as adverse effects. Of the 938 publications identified by the search strategies, 74 met the inclusion criteria. We identified 23 animal trials, 50 human, and 1 animal case reports. Overall, the quality of evidence was weak and significant heterogeneity prevented data pooling. Available data suggest some benefits ...Continue Reading

References

Aug 15, 1974·Experientia·J KrieglsteinD H Niemeyer
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Sep 24, 1999·JAMA : the Journal of the American Medical Association·P JüniMatthias Egger
May 29, 2003·Regional Anesthesia and Pain Medicine·Guy L WeinbergWilliam Hoffman
Sep 1, 1962·Anesthesia and Analgesia·R L RUSSELL, B A WESTFALL
Mar 31, 2005·Emergency Medicine Australasia : EMA·Grant CaveCraig D Castle
Jan 27, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Simon TebbuttGrant Cave
Nov 14, 2006·Annals of Emergency Medicine·Martyn Harvey, Grant Cave
Sep 27, 2007·The Annals of Pharmacotherapy·Shelby L Corman, Susan J Skledar
Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Grant CaveCraig D Castle
Feb 5, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·J-M MalinovskyComité douleur-anesthésie locorégionale de Sfar
Feb 27, 2008·Regional Anesthesia and Pain Medicine·Thomas McCutchen, J C Gerancher
Mar 26, 2008·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Mary K Clark
Apr 19, 2008·Anesthesia and Analgesia·Guy L Weinberg
Apr 24, 2008·Anesthesiology·Guy L WeinbergDouglas L Feinstein
Jun 24, 2008·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Martyn Harvey, Grant Cave
Jun 24, 2008·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Danielle E Turner-Lawrence, William Kerns Ii
Sep 30, 2008·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Kristen Felice, Heather Schumann
Dec 10, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alvin C BronsteinAmerican Association of Poison Control Centers
Jan 13, 2009·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Martyn HarveyKerry Hoggett
Mar 14, 2009·Resuscitation·Amy C YoungKurt C Kleinschmidt
Mar 21, 2009·Anesthesia and Analgesia·Peter C MarwickAndre R Coetzee
May 14, 2009·Regional Anesthesia and Pain Medicine·Stephen Markowitz, Joseph M Neal
May 14, 2009·Regional Anesthesia and Pain Medicine·Hélène CharbonneauDan Benhamou
May 14, 2009·Regional Anesthesia and Pain Medicine·Alexandre GnahoMarc Gentili

Citations

Aug 8, 2013·Medizinische Klinik, Intensivmedizin und Notfallmedizin·K Hruby
Mar 26, 2011·Der Anaesthesist·V HugeJ Briegel
Dec 22, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Samuel J StellpflugJoel S Holger
Oct 13, 2011·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Ann-Jeannette GeibToxicology Investigators’ Consortium (ToxIC)
Sep 12, 2012·Case Reports in Pediatrics·Michael FroehleEugen Sandica
Oct 7, 2010·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Leelach RothschildGuy L Weinberg
Feb 3, 2012·International Journal of Emergency Medicine·Martyn Harvey, Grant Cave
Jul 13, 2012·Clinical Medicine : Journal of the Royal College of Physicians of London·D N Bateman
Nov 29, 2012·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Hossein Sanaei-Zadeh
Dec 18, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Michael LevineAnthony F Pizon
Jun 28, 2014·BioMed Research International·Mohammad MoshiriHossein Hosseinzadeh
Jan 15, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Grant CaveGuy L Weinberg
Nov 1, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Ravi AgarwalaTimothy J Wiegand
Jun 24, 2014·Annales Françaises D'anesthèsie Et De Rèanimation·K Nouette-GaulainH Beloeil
Feb 13, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Jon B ColeKristin M Engebretsen
Oct 2, 2014·The Journal of Emergency Medicine·Betzaida RodríguezKenneth E Kokko
May 20, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Changwoo KangDong Hoon Lee
Jun 19, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Malin Bartos, Kai Knudsen
May 25, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Grant CaveD Heys
Jan 31, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hwee Min D LeeDavid M Wood
Nov 11, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jeena Jacob, Kennon Heard
Feb 9, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lotte C G HoegbergLipid Emulsion Workgroup
Jul 12, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jasmina Jovic-StosicRadenko Spasic
Jul 19, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·A H Dawson, M F Wilks
Jul 23, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hyo-Wook GilSae-Yong Hong
Jun 24, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sang Kyoon HanSungwook Park
Oct 26, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kristin M EngebretsenJoel S Holger
Aug 9, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Birkitt L ten TusscherRoelof W F van Leeuwen
Aug 10, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Pierre Etienne MoussotJean-Louis Ducassé
Sep 14, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·T L SamuelsJ W Willers
Jun 11, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sophie GosselinAACT Lipid Emulsion Therapy workgroup
Nov 21, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jinwoo Jeong
Oct 19, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ami M GrunbaumDavid W Blank
Apr 7, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Patrick L WestRobert Hendrickson
Mar 1, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ruben HaesendonckMarc B Sabbe
Oct 6, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Allan R MottramJonathan C Makielski
May 14, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Soeren BoegevigLotte C G Hoegberg
Nov 10, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·J Von Der WellenT Wille
Jan 20, 2011·Journal of Pharmaceutical Sciences·Rebecca A JohnsonSandro Mecozzi
Mar 3, 2012·The Veterinary Clinics of North America. Small Animal Practice·Valentina M Merola, Paul A Eubig
Feb 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Grant Cave, Martyn Harvey
Mar 15, 2016·The Journal of Emergency Medicine·Samuel H F LamGary M Vilke
Sep 15, 2015·British Journal of Clinical Pharmacology·Michael Eddleston, Fazle Rabbi Chowdhury
May 10, 2013·Journal of Veterinary Emergency and Critical Care·Barbara L MatonAmy J Alwood
Aug 14, 2012·Pacing and Clinical Electrophysiology : PACE·Heather EllsworthCarson R Harris
Dec 12, 2012·Anaesthesia·G T C Wong, M G Irwin
Jul 6, 2011·Basic & Clinical Pharmacology & Toxicology·Zhanna LivshitsRobert S Hoffman
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Heather M WrightKatrina L Mealey
Jan 4, 2012·Paediatric Anaesthesia·Guy L Weinberg, Santhanam Suresh
Apr 15, 2011·Emergency Medicine Australasia : EMA·Guy L Weinberg
Feb 3, 2011·Emergency Medicine Australasia : EMA·Naren Gunja, Andis Graudins
Jan 16, 2013·Journal of Veterinary Emergency and Critical Care·Steven E Epstein, Steven R Hollingsworth
Jul 30, 2014·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Sundeep ShenoySasikanth Adigopula
May 5, 2011·Critical Care Research and Practice·Martyn HarveyGary Hopgood
May 2, 2016·The American Journal of Emergency Medicine·Theodoros XanthosNicoletta Iacovidou
Mar 3, 2015·The Journal of Small Animal Practice·N BatesN Edwards
Jul 29, 2015·Advanced Emergency Nursing Journal·Amy E SchultzStephanie Baker Justice
Jun 3, 2015·Clinical Medicine : Journal of the Royal College of Physicians of London·Omar MukhtarDavid M Wood
Jun 17, 2015·Case Reports in Emergency Medicine·Gökhan AkselŞebnem Eren Çevik
Dec 24, 2014·The Journal of Emergency Medicine·Dazhe CaoAlex Koyfman
Sep 7, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Michael E Mullins
Jun 4, 2016·Journal of the American Animal Hospital Association·Brittany Heggem-PerryClara Moran
May 3, 2016·Basic & Clinical Pharmacology & Toxicology·Jonas HöjerP H Rosenberg
Dec 20, 2016·Journal of Veterinary Emergency and Critical Care·Whitney M LongDanielle Thomas
Mar 17, 2017·São Paulo Medical Journal = Revista Paulista De Medicina·Luciane Cristina Rodrigues FernandesFábio Bucaretchi
Jun 30, 2011·Journal of Pharmacy Practice·Simon W LamSeth R Bauer
Apr 12, 2018·Advanced Materials·Duo XuCheng Ji
Apr 13, 2018·Nutrients·Eliza L GordonLisa J Merlo
Jan 15, 2014·Hospital Pharmacy·Calvin J MeaneyJeffrey P Gonzales
May 27, 2011·Critical Care Medicine·Grant Cave, Martyn Harvey
May 23, 2012·Journal of the American Animal Hospital Association·Amy Kaplan, Megan Whelan
Aug 28, 2013·The Journal of Pharmacology and Experimental Therapeutics·Nicholas J Connors, Robert S Hoffman
Aug 23, 2019·Journal of Clinical Pharmacy and Therapeutics·Motozumi AndoTohru Hashida
Jan 23, 2015·A & a Case Reports·Matthew Bowler, Daniel Robert Nethercott
Jul 13, 2016·Anesthesiology·Martyn Harvey, Grant Cave
Oct 4, 2019·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Julia Tschirdewahn, Florian Eyer
Mar 3, 2020·BMJ Case Reports·Rashpal Ghataoura, Shashank Patil
Apr 15, 2011·Emergency Medicine Australasia : EMA·Grant CaveAndis Graudins
Apr 25, 2013·The Annals of Pharmacotherapy·Joseph D Presley, Peter A Chyka
Jan 22, 2014·Toxicology and Industrial Health·Mohammad MoshiriHossein Hosseinzadeh
Apr 1, 2016·Anaesthesia and Intensive Care·J A HeinonenE Litonius
Oct 23, 2019·Journal of Veterinary Emergency and Critical Care·Rachel B DavyAlex M Lynch

Related Concepts

Clinical Trials
Drug Interactions
Fat Emulsions, Intravenous
Poisoning
Adrenergic beta-Antagonists
Bupivacaine
Chlorpromazine
Clinical Investigators
Clinical Trials
Fat Emulsions, Intravenous

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Grant Cave, Martyn Harvey
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Samuel J StellpflugJoel S Holger
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Sang Kyoon HanSungwook Park
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Deborah FrenchAlan H B Wu
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Kristin M EngebretsenJoel S Holger
© 2021 Meta ULC. All rights reserved