Lipid extract from completely sporoderm-broken germinating Ganoderma sinensis spores elicits potent antitumor immune responses in human macrophages

Phytotherapy Research : PTR
Jing-Ping ZhangXin Liu

Abstract

Ganoderma sinensis has been used widely in Oriental countries for the prevention and treatment of various diseases including cancer. Previous studies have shown that the lipid extract from Ganoderma exhibits direct cytotoxicity against tumor cells. Here, it is reported that the lipid extract from germinating G. sinensis spores, at lower concentrations that have no direct tumoricidal activity, induce potent antitumor immune responses in human monocytes/macrophages. Upon stimulation with the lipid extract, monocytes/macrophages exhibited markedly increased production of proinflammatory cytokines and surface expression of costimulatory molecules. Conditioned medium from stimulated cells effectively suppressed the growth of tumor cells. Apparently, the lipid extract triggered macrophage activation via a mechanism different from that associated with LPS. Moreover, it was observed that the lipid extract could partially re-establish the antitumor activity of the immunosuppressive tumor-associated macrophages. These results indicated that in addition to its direct tumoricidal activity, the lipid extract from G. sinensis spores could exert antitumor activity by stimulating the activation of human monocytes/macrophages.

References

Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J L UrbanH Schreiber
Mar 17, 1997·International Journal of Cancer. Journal International Du Cancer·S Y WangC K Ho
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A SicaA Mantovani
Feb 16, 2000·Lancet·A Fugh-Berman
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A E MedvedevS N Vogel
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Aug 25, 2001·Journal of Natural Products·T S WuS C Kuo
Jan 8, 2003·Seminars in Oncology·Isaac CohenDebu Tripathy
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatsushi KatakuraFujio Suzuki
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hsien-Yeh HsuChi-Huey Wong
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Limin ZhengOlle Stendahl
Nov 16, 2005·International Journal of Cancer. Journal International Du Cancer·Teruhisa SakamotoMasahide Ikeguchi
Jan 10, 2006·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Wing Keung ChanGodfrey Chi-Fung Chan
Jan 21, 2006·Cancer Research·Claire E Lewis, Jeffrey W Pollard
Jan 25, 2006·Journal of Nanoscience and Nanotechnology·Xin LiuJian-Ping Yuan
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie K WatkinsRobert D Stout
Apr 21, 2007·Analytical and Bioanalytical Chemistry·Xin LiuXiao-Ni Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.