Lipid gene nanocarriers for the treatment of skin diseases: Current state-of-the-art

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Coralie BellefroidGéraldine Piel

Abstract

Nucleic acids carried by non-viral nanovectors have demonstrated high potential as a therapeutic strategy for gene-related diseases. The dermal or transdermal gene delivery allow to target local skin diseases or to reach the blood stream. However, the skin is the first defense barrier of the body and must be overcome to distribute nucleic acids. Many intracellular barriers as cellular uptake, endosomal escape or cytosolic gene trafficking have to be crossed for the gene to achieve its therapeutic action. All hurdles to skin nucleic acid therapy are precisely described. Physical, active or passive methods have been proposed to improve the penetration through the stratum corneum. Lipidic-nanocarriers represent one of the most attractive methods because any skin disruption technique is requested. We give an overview of deformable lipidic-nanocarriers that have been developed to promote the skin penetration of nucleic acids. Moreover, this review describes the potential of deformable liposomes for cutaneous disorders.

Citations

Dec 13, 2019·Expert Opinion on Drug Delivery·Alexa Patzelt, Juergen Lademann
Nov 13, 2019·International Journal of Pharmaceutics·C BellefroidG Piel
Feb 3, 2021·Nanomaterials·Noriyuki UchidaHiroki Hamada
Jul 5, 2021·International Journal of Pharmaceutics·Manon BergerGéraldine Piel
Mar 3, 2020·Advanced Drug Delivery Reviews·Livia Neves Borgheti-CardosoMaria Vitória Lopes Badra Bentley
Nov 10, 2021·Biomaterials Science·Shuyao RuanNianping Feng
Sep 8, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Gülşah Erel-Akbaba, Hasan Akbaba
Oct 14, 2020·European Journal of Pharmacology·Bharath Singh PadyaSrinivas Mutalik

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