PMID: 2491758Jan 1, 1989Paper

Lipid hydroperoxides inhibit reacylation of phospholipids in neuronal membranes

Journal of Neurochemistry
M M Zaleska, D F Wilson

Abstract

The unsaturated fatty acids that rapidly accumulate during ischemia are thought to participate in inducing irreversible brain injury, especially because they are highly susceptible to peroxidation when the tissue is reoxygenated. Our hypothesis was that peroxidation products of unsaturated fatty acids interfere with the reacylation of synaptic phospholipids, a process essential to membrane repair. To test this hypothesis, we have examined the effect of fatty acid hydroperoxides on incorporation of [1-14C]arachidonic acid into synaptosomal phospholipids. Rat forebrain synaptosomes were incubated with arachidonic or linoleic acid hydroperoxides and [14C]arachidonate, and then lipids were extracted and separated by TLC. Both hydroperoxides inhibited [14C]arachidonate incorporation into phospholipids in a concentration-dependent manner, with 50% inhibition occurring at less than 25 microM hydroperoxide, in both the absence and presence of exogenous lysophospholipids. The inhibition was of the non-competitive type. It is concluded that (a) low levels of fatty acid hydroperoxides inhibit the reacylation of synaptosomal phospholipids, and (b) this inhibition may constitute an important mechanism whereby peroxidative processes contribu...Continue Reading

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Citations

Jan 1, 1994·Pharmacology & Therapeutics·M E GötzM B Youdim
Aug 1, 1995·Progress in Neurobiology·H Katsuki, S Okuda
Oct 1, 1994·Free Radical Biology & Medicine·E H PacificiA Sevanian
Aug 26, 1998·Biochimica Et Biophysica Acta·N V RalstonH H Schmid
Oct 31, 2000·Journal of the Neurological Sciences·B C WhiteG S Krause
Sep 30, 1998·Journal of Neurotrauma·W M Armstead
Jan 1, 1991·Journal of Neurochemistry·P VianiB Cestaro
Aug 23, 2006·Journal of Neurochemistry·Savita KhannaChandan K Sen
Dec 1, 1992·Chemico-biological Interactions·A Van der Vliet, A Bast
Jan 1, 1989·Annals of the New York Academy of Sciences·N G Bazan
Jun 2, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·William M Armstead
Sep 6, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C N Bennett, D F Horrobin
Mar 22, 2003·Blood·Fausta Omodeo-SalèDonatella Taramelli
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R N CornelussenL H Snoeckx
May 1, 1991·Brain Research. Brain Research Reviews·A A Farooqui, L A Horrocks
Aug 1, 1991·Archives of Biochemistry and Biophysics·E H Kim, A Sevanian

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