Lipid-induced mitochondrial stress and insulin action in muscle.

Cell Metabolism
Deborah M Muoio, P Darrell Neufer

Abstract

The interplay between mitochondrial energetics, lipid balance, and muscle insulin sensitivity has remained a topic of intense interest and debate for decades. One popular view suggests that increased oxidative capacity benefits metabolic wellness, based on the premise that it is healthier to burn fat than glucose. Attempts to test this hypothesis using genetically modified mouse models have produced contradictory results and instead link muscle insulin resistance to excessive fat oxidation, acylcarnitine production, and increased mitochondrial H(2)O(2)-emitting potential. Here, we consider emerging evidence that insulin action in muscle is driven principally by mitochondrial load and redox signaling rather than oxidative capacity.

References

Aug 1, 1992·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M BarnettK O'Dea
Aug 1, 1966·The Biochemical Journal·R M Denton, P J Randle
Nov 25, 1997·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A HübingerF A Gries
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·B DesvergneW Wahli
May 29, 2000·The Journal of Biological Chemistry·M Guerre-MilloB Staels
Jul 21, 2000·The Journal of Clinical Investigation·G I Shulman
Sep 28, 2002·Diabetes·David E KelleyVladimir B Ritov
Mar 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Matthew W HulverJoseph A Houmard
May 17, 2003·Science·Kitt Falk PetersenGerald I Shulman
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mary Elizabeth PattiLawrence J Mandarino
Aug 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lutfi Abu-ElheigaSalih J Wakil
Feb 13, 2004·The New England Journal of Medicine·Kitt Falk PetersenGerald I Shulman
Dec 24, 2004·Diabetes·Vladimir B RitovDavid E Kelley
Jan 22, 2005·Science·Bradford B Lowell, Gerald I Shulman
Jul 7, 2005·Antioxidants & Redox Signaling·Joseph L EvansIra D Goldfine
Dec 17, 2005·Antioxidants & Redox Signaling·Asnat Bloch-Damti, Nava Bashan
Dec 31, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M Roden
Mar 21, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A E M VickersR L Fisher
Nov 30, 2006·Archives of Physiology and Biochemistry·Mary C Sugden, Mark J Holness
Feb 21, 2007·Diabetologia·R A PowerR L Mynatt
Jul 20, 2007·American Journal of Physiology. Endocrinology and Metabolism·Robert C NolandRonald N Cortright
Oct 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cheol Soo ChoiGerald I Shulman
Jan 12, 2008·The Journal of Clinical Investigation·Charlotte BonnardJennifer Rieusset
Mar 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Simon T Y HuiRoger A Davis
Apr 24, 2008·American Journal of Physiology. Endocrinology and Metabolism·Nam Ho Jeoung, Robert A Harris
May 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Edward W KraegenNigel Turner
May 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chad R HancockJohn O Holloszy
Aug 8, 2008·American Journal of Physiology. Cell Physiology·Dean P Jones

❮ Previous
Next ❯

Citations

Aug 21, 2012·Antioxidants & Redox Signaling·Dolors SerraLaura Herrero
Jun 16, 2012·The Journal of Pharmacology and Experimental Therapeutics·Laura A A Gilliam, P Darrell Neufer
Aug 23, 2012·American Journal of Physiology. Endocrinology and Metabolism·Mark D PetersonCharles F Burant
Feb 5, 2013·The Journal of Clinical Investigation·Katsuhiko FunaiClay F Semenkovich
Jun 12, 2014·Metabolic Syndrome and Related Disorders·Raymond J CroniseAndrew A Bremer
Feb 24, 2016·Biochimica Et Biophysica Acta·Igor ZlobineJohn R Ussher
Sep 28, 2013·The Journal of Nutritional Biochemistry·Julia BolsingerK C Hayes
Jun 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shawna E WicksRandall L Mynatt
Jul 8, 2016·Adipocyte·María Calderon-DominguezLaura Herrero
Oct 13, 2015·Metabolism: Clinical and Experimental·Kirti KaulMichael Roden
Sep 26, 2015·Canadian Journal of Physiology and Pharmacology·Silvana Constantinescu, Lorraine P Turcotte
Sep 10, 2014·Diabetes, Obesity & Metabolism·B WesselsJ J Prompers
Mar 29, 2014·Molecular Nutrition & Food Research·Zhiyong ChengMatthew W Hulver
Aug 8, 2015·Biochimie·Shawna E WicksKrisztian Stadler
Aug 21, 2014·Diabetes/metabolism Research and Reviews·Mohamad Hafizi Abu BakarHasniza Zaman Huri
Apr 17, 2016·European Journal of Pharmacology·Aoife A CookeHelen M Roche
Feb 26, 2014·Molecular Metabolism·Kenneth A DyarStefano Schiaffino
Jun 26, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Olesja RitterMichael Roden
Mar 13, 2015·Antioxidants & Redox Signaling·Joel D Schilling
Mar 5, 2015·Antioxidants & Redox Signaling·Anne D HafstadEllen Aasum
Feb 13, 2015·Antioxidants & Redox Signaling·Miguel A AonSonia Cortassa
Feb 21, 2014·Cell Cycle·Zhiyong Cheng, Fabio A Almeida
Jun 28, 2013·Adipocyte·Alexandra C McPherronOksana Gavrilova
Feb 19, 2013·Cell·Andrew M F Johnson, Jerrold M Olefsky
Aug 19, 2014·Frontiers in Physiology·Miguel A AonSonia C Cortassa

❮ Previous
Next ❯