Lipid infiltration as a possible biologic cause of silicone gel breast implant aging

Plastic and Reconstructive Surgery
W P AdamsR J Rohrich

Abstract

The cause of silicone gel implant aging and rupture is not known. Recent reports indicate the failure rate is higher than previously published, and implant aging and rupture may be due to progressive mechanical deterioration of the outer vulcanized silicone shell. It is known that lipids are absorbed by the hydrophobic silicone elastomer, and lipid infiltration causes mechanical attenuation and possible failure of the elastomer. The purposes of this article are to analyze the silicone envelope/gel of explanted prostheses and the silicone elastomer of other medical grade silicone devices for lipid content and to suggest its possible role in implant aging and rupture. We assayed 33 ruptured silicone breast implant shells (mean age 13.1 years; range 8 to 26 years) and 8 medical grade silicone elastomer devices (mean age 3.7 years; range 3 months to 12 years) for evidence of lipid infiltration using thin layer chromatography. These were compared with control group assays from two nonimplanted silicone gel implants and one unused Silastic catheter. Ninety-eight percent of implants and other previously implanted silicone devices were found to have evidence of lipid infiltration compared with none in nonimplanted controls (p < 0.005)....Continue Reading

References

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Citations

Mar 30, 2004·Biomaterials·Anja Britta BirkefeldBettina Pfleiderer
Jun 7, 2003·British Journal of Plastic Surgery·Adam ToppingGeoffrey Wilson
Feb 2, 2000·Plastic and Reconstructive Surgery·L J Feng, S B Amini
Nov 17, 2001·Plastic and Reconstructive Surgery·J M LassoA Bazán
Apr 28, 2004·Plastic and Reconstructive Surgery·Stan MonstreyPhillip Blondeel
Feb 14, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·S OulharjY Tropet
Aug 29, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·M G Berry, D M Davies
Mar 10, 2015·Journal of the Mechanical Behavior of Biomedical Materials·F BodinF Heim
Sep 11, 2003·Annals of Plastic Surgery·Silvia CicchettiPier Luigi Santi
Oct 5, 2018·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Laura J LeslieVik Vijh
Apr 22, 2003·In Vitro Cellular & Developmental Biology. Animal·Hua AiSteven A Jones
Sep 16, 2005·Plastic and Reconstructive Surgery·Nicolò ScuderiMaria Giuseppina Onesti

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