Lipid levels and peripheral vascular disease in diabetic and non-diabetic subjects

Atherosclerosis
D N O'NealJ D Best

Abstract

Non-insulin dependent diabetes (NIDDM) is associated with an increased risk of peripheral vascular disease (PVD), but within the diabetic population the relationship between lipid profile and PVD has not been clearly defined. In this study we examined the association of lipid parameters and in particular low density lipoprotein (LDL) particle size, with the presence of PVD in subjects with and without NIDDM. 41 NIDDM patients and 31 non-diabetic subjects with PVD in the absence of rest pain or ulceration, defined by ankle-brachial index measurements and duplex scanning, were compared with 41 NIDDM and 31 euglycemic control subjects of comparable age and sex, without PVD. In both groups those with PVD were found to have significantly elevated triglycerides (2.7 [2.2-3.3] versus 1.9 [1.6-2.2] mmol/l; P < 0.05 in the diabetic group and 2.0 [1.6-2.3] versus 1.4 [1.1-1.5] mmol/l; P < 0.05 in the non-diabetic group), decreased apolipoprotein A1 (124 +/- 3 versus 139 +/- 5 mg/dl; P < 0.01 in the diabetic group and 133 +/- 4 versus 147 +/- 4 mg/dl; P < 0.05 in the non-diabetic group) and decreased LDL particle size (25.4 +/- 0.1 versus 25.8 +/- 0.1 nm; P < 0.01 in the diabetic group and 26.0 +/- 0.1 versus 26.3 +/- 0.1 nm; P < 0.05 in ...Continue Reading

References

Dec 16, 1978·Lancet·G V BradbyK W Walton
May 27, 1978·British Medical Journal·W G HughsonA Garrod
Mar 1, 1977·British Journal of Preventive & Social Medicine·G RoseD D Reid
Feb 11, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H CamposE J Schaefer
Dec 1, 1991·Diabetes Care·M P Stern, S M Haffner
Jun 1, 1988·International Journal of Epidemiology·F G Fowkes
Jan 1, 1988·Age and Ageing·W E HaleR B Stewart
Oct 7, 1988·JAMA : the Journal of the American Medical Association·M A AustinR M Krauss
Sep 1, 1988·Metabolism: Clinical and Experimental·K SammalkorpiM R Taskinen
Jan 1, 1986·Methods in Enzymology·B H ChungJ T Cone
Oct 30, 1971·Lancet·R M GreenhalghP Martin
Aug 1, 1973·Archives of Surgery·A J Rosen, R G DePalma
Jun 1, 1982·The Surgical Clinics of North America·E F Bernstein, A Fronek
Jan 1, 1982·Acta Medica Scandinavica·A ReunanenA Aromaa
Sep 1, 1993·Annals of Vascular Surgery·M D Widmann, B E Sumpio
Jul 1, 1993·The Journal of Clinical Investigation·G M ReavenR M Krauss
Jan 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D O'NealJ Best
Sep 21, 1963·British Medical Journal·W C WATSONC DICKSON

❮ Previous
Next ❯

Citations

Oct 16, 2007·International Journal of Clinical Practice·M Rizzo, K Berneis
Jun 14, 2000·Drugs·J D Best, D N O'Neal
May 13, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kaspar BerneisGiovam Battista Rini
Feb 4, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·E B JudeN Tentolouris
Mar 31, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·H-I YuY-T Chen
Dec 8, 2006·Expert Opinion on Biological Therapy·Irene F GaziDimitri P Mikhailidis
Jul 25, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A Dionyssiou-AsteriouE Bastounis
Oct 23, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A Dionyssiou-AsteriouE Bastounis
Feb 22, 2012·European Journal of Preventive Cardiology·Joanne N LukeKevin G Rowley
Oct 31, 2000·Diabetes/metabolism Research and Reviews·N C SchaperM S Huijberts
Jan 30, 2015·Journal of Clinical Neurology·Tae-Jin SongYong-Jae Kim
Nov 3, 2006·Diabetes/metabolism Research and Reviews·Manfredi Rizzo, Kaspar Berneis
Dec 24, 2005·QJM : Monthly Journal of the Association of Physicians·M Rizzo, K Berneis
Feb 25, 2021·European Journal of Preventive Cardiology·Francesco ForteMatteo Nicola Dario Di Minno
Feb 24, 2006·European Journal of Internal Medicine·Manfredi Rizzo, Kaspar Berneis
Apr 21, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Manfredi RizzoJelena Vekic

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.