Feb 1, 2019

Lipid-Lowering Agents

Circulation Research
Robert A Hegele, Sotirios Tsimikas


Several new or emerging drugs for dyslipidemia owe their existence, in part, to human genetic evidence, such as observations in families with rare genetic disorders or in Mendelian randomization studies. Much effort has been directed to agents that reduce LDL (low-density lipoprotein) cholesterol, triglyceride, and Lp[a] (lipoprotein[a]), with some sustained programs on agents to raise HDL (high-density lipoprotein) cholesterol. Lomitapide, mipomersen, AAV8.TBG.hLDLR, inclisiran, bempedoic acid, and gemcabene primarily target LDL cholesterol. Alipogene tiparvovec, pradigastat, and volanesorsen primarily target elevated triglycerides, whereas evinacumab and IONIS-ANGPTL3-LRx target both LDL cholesterol and triglyceride. IONIS-APO(a)-LRx targets Lp(a).

  • References208
  • Citations13


Mentioned in this Paper

Lipoprotein (a-)
Monoclonal Antibodies
Mendelian Randomization Analysis
Mipomersen sodium
Diglyceride Acyltransferase 1
Dicarboxylic Acids
ANGPTL3 protein, human

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