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Lipid lowering and Alzheimer's disease risk: a Mendelian randomization study

Annals of Neurology

Nov 12, 2019

Dylan M. WilliamsAroon Dinesh Hingorani

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Abstract

To examine whether genetic variation affecting the expression or function of lipid-lowering drug targets is associated with Alzheimer's disease (AD) risk, to evaluate the potential impact of long-term exposure to corresponding therapeutics. We conducted Mendelian randomization analyses ...read more

Mentioned in this Paper

Alzheimer's Disease
Antilipemic agent
Genes
Lipids
LDL Cholesterol Lipoproteins
Magnetic Resonance Imaging
Prophylactic Treatment
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Gene Mutant
Meta Analysis (Statistical Procedure)
30
2
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Lipid lowering and Alzheimer's disease risk: a Mendelian randomization study

Annals of Neurology

Nov 12, 2019

Dylan M. WilliamsAroon Dinesh Hingorani

PMID: 31714636

DOI: 10.1002/ana.25642

Abstract

To examine whether genetic variation affecting the expression or function of lipid-lowering drug targets is associated with Alzheimer's disease (AD) risk, to evaluate the potential impact of long-term exposure to corresponding therapeutics. We conducted Mendelian randomization analyses ...read more

Mentioned in this Paper

Alzheimer's Disease
Antilipemic agent
Genes
Lipids
LDL Cholesterol Lipoproteins
30
2

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