Lipid-lowering drugs (statins) and peripheral neuropathy

Electronic Physician
Mohammadreza EmadBahareh Kardeh

Abstract

Peripheral neuropathy is a disorder with often unknown causes. Some drugs, including statins, are proposed to be among the causes of peripheral neuropathy. This study aimed at evaluating this condition by electrodiagnostic study among patients who had received statins. This case-control study was conducted in Shiraz, Iran in 2015, and included 39 patients aged 35-55 who had received statins for at least 6 months, and 39 healthy matched controls. Using electrodiagnosis, the sensory and motor wave features (amplitude, latency and nerve conduction velocity) of the peripheral nerves (Median, Ulnar, Tibial, Sural, and Peroneal) were evaluated among the subjects. Data were analyzed using SPSS software and p<0.05 was considered statistically significant. Regarding the occurrence of neuropathy, there were no significant differences in any of the definitions presented for peripheral neuropathy. However, the difference was close to significance for one definition [2 abnormalities in 2 nerves (p=0.055)]. Regarding mean values of the features, significant differences were observed in two features: amplitude of the peroneal motor nerve (p=0.048) and amplitude of the sural sensory nerve (p=0.036). Since statins are widely used, awareness reg...Continue Reading

Citations

Sep 11, 2019·Basic & Clinical Pharmacology & Toxicology·Toke de Koning SvendsenDavid Gaist
Feb 6, 2020·Pain and Therapy·Joseph V PergolizziRobert Taylor
Dec 19, 2020·Central European Journal of Public Health·Romana UlbrichtováHenrieta Hudečková
Feb 26, 2021·Journal of Clinical Pharmacy and Therapeutics·Miao WangYing Xie
Apr 20, 2020·Diabetes & Metabolic Syndrome·Mohamed A HammadDzul Azri Mohamed Noor
Jul 22, 2021·Current Cancer Drug Targets·Diala MerhebHazem I Assi

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