Lipid-lowering efficacy of atorvastatin

The Cochrane Database of Systematic Reviews
Stephen P AdamsJames M Wright

Abstract

This represents the first update of this review, which was published in 2012. Atorvastatin is one of the most widely prescribed drugs and the most widely prescribed statin in the world. It is therefore important to know the dose-related magnitude of effect of atorvastatin on blood lipids. Primary objective To quantify the effects of various doses of atorvastatin on serum total cholesterol, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and triglycerides in individuals with and without evidence of cardiovascular disease. The primary focus of this review was determination of the mean per cent change from baseline of LDL-cholesterol. Secondary objectives • To quantify the variability of effects of various doses of atorvastatin.• To quantify withdrawals due to adverse effects (WDAEs) in placebo-controlled randomised controlled trials (RCTs). We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue 11, 2013), MEDLINE (1966 to December Week 2 2013), EMBASE (1980 to December Week 2 2013), Web of Science (1899 to December Week 2 2013) and BIOSIS Previews (1969 to December Week 2 2013). We applied no language restrictions. Randomised controlled and uncontrolled before-and-aft...Continue Reading

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Citations

Jan 12, 2017·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Serena Tonstad
Mar 7, 2018·The Cochrane Database of Systematic Reviews·Stephen P AdamsJames M Wright
Aug 5, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Tamio TeramotoMasahiro Murakami
May 29, 2018·Current Infectious Disease Reports·Mosepele MosepeleVirginia A Triant
Jan 26, 2020·The Cochrane Database of Systematic Reviews·Stephen P AdamsJames M Wright
Feb 29, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Nuntakorn ThongtangSutin Sriussadaporn
Jul 16, 2020·The Cochrane Database of Systematic Reviews·Cho Naing, Han Ni
Jun 21, 2019·Current Opinion in Lipidology·Handrean SoranPaul N Durrington
Jun 20, 2020·The Cochrane Database of Systematic Reviews·Stephen P AdamsJames M Wright
Jan 23, 2021·The Cochrane Database of Systematic Reviews·Muhammad Ismail ShawishJames M Wright
Jun 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Negin ParsamaneshAmirhossein Sahebkar

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