Lipid-lowering medications for children and adolescents

Journal of Clinical Lipidology
Melissa L MillerBarry Browne

Abstract

As demonstrated by the 2011 publication of the National Heart, Lung, and Blood Institute Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, the information available regarding the treatment of pediatric lipid disorders has greatly expanded. HMG-CoA reductase inhibitor, or statin, therapy is now considered a first-line pharmacologic intervention for pediatric patients with severe dyslipidemias failing treatment with diet and exercise alone. Despite their ability to effectively reduce cholesterol levels, bile acid sequestrants continue to pose challenges for pediatric patients because of their unpalatability and are typically used as adjunctive therapy or for patients not able to tolerate statins. Fibric acid derivatives, as a class of medications, not only lack a Food and Drug Administration (FDA)-approved agent, but also continue to lack significant pediatric safety and efficacy data. Niacin, a potential adjunct therapy, lacks FDA approval for pediatric patients and is plagued by significant adverse effects making it an unlikely therapy option for pediatric patients. Ezetimibe provides clinicians with an alternative adjunct therapy option when synergistically paired with an HMG-CoA r...Continue Reading

References

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Citations

Sep 1, 2016·Journal of Clinical Lipidology·Nina R JoyceJustin P Zachariah
Sep 3, 2017·Pediatrics in Review·Badhma ValaiyapathiAmbika P Ashraf
Jan 4, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Margret E BockJens Goebel
Dec 7, 2018·Expert Opinion on Pharmacotherapy·Dragana NikolicManfredi Rizzo
Aug 8, 2021·The Journal of Clinical Endocrinology and Metabolism·Ambika P AshrafBrenda Kohn
Oct 6, 2020·Hormone Research in Pædiatrics·Veronica Maria TagiFrancesco Chiarelli

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