Lipid lymphocyte chemoattractants in psoriasis

Prostaglandins
K B Bacon, R D Camp

Abstract

In view of the evidence that lymphocyte infiltrates are a constant feature of the skin lesions of psoriasis and the demonstration that certain hydroxylated metabolites of arachidonic acid are present in lesional psoriatic skin and possess lymphocyte chemoattractant properties, lipid extracts of samples from lesional and normal skin were assayed to determine which are the predominant lipid lymphocyte chemoattractants in psoriasis. Dilution-related lymphocyte chemoattractant activity was found in lipid extracts of stratum corneum samples from psoriatic lesions, but not in similar extracts of stratum corneum from the heels of normal volunteers, whereas aqueous extracts of the samples from both sources contained equivalent amounts of this activity. Subsequent purification of lesional stratum corneum lipid extracts by straight and reversed phase high performance liquid chromatography (HPLC) revealed the presence of at least two different lipid chemoattractants, one major component being identified as 12-(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12[R]-HETE) by its biological and chromatographic properties. These compounds may play a role in the pathogenesis of the lymphocyte infiltrates in psoriatic lesions.

References

Mar 1, 1979·International Journal of Dermatology·G L Grove
Mar 25, 1977·Archives of Dermatological Research·O Braun-Falco, C Schmoeckel
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S HammarströmJ J Voorhees
Oct 1, 1985·The Journal of Clinical Investigation·L C GahringR A Daynes
Dec 12, 1986·JAMA : the Journal of the American Medical Association·C N EllisT M Annesley
Feb 1, 1988·The British Journal of Dermatology·T Van JoostM M Meinardi
Apr 14, 1986·Biochemical and Biophysical Research Communications·P M Woollard
Jan 16, 1985·Biochemical and Biophysical Research Communications·A I Mallet, F M Cunningham
Sep 1, 1984·British Journal of Pharmacology·S D BrainA K Black
Jan 1, 1984·The British Journal of Dermatology·B S BakerL Fry
Sep 1, 1983·Prostaglandins·R D CampM W Greaves

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Citations

Mar 1, 1995·Clinics in Dermatology·J M Schröder
Sep 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D J FretlandT S Gaginella
Jan 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F Grimminger, P Mayser

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