Lipid mediators in the pathophysiology of critical illness

Critical Care Medicine
E M Bulger, R V Maier

Abstract

Inflammatory lipid mediators are produced by the metabolism of membrane phospholipids following a number of different stimuli. These mediators lead to a variety of cellular and systemic responses which contribute to the manifestations of the systemic inflammatory response syndrome in the critically ill patient. These mediators include platelet-activating factor and the eicosanoids, including prostaglandins, thromboxanes, leukotrienes, and HETEs. This review seeks to evaluate the current role of these mediators in the pathophysiology of critical illness. We will focus on recent studies concerning the modulation of these pathways as a potential therapeutic strategy for management of these critically ill patients. This includes the gamut from nutritional strategies to alter the cellular membrane lipid composition, thereby effecting the substrate available to produce these lipid byproducts, to intracellular inhibitors to alter production of these mediators, to receptor blockage and enhanced clearance to inhibit their effects.

References

Dec 23, 1992·JAMA : the Journal of the American Medical Association·R C Bone
Mar 1, 1992·The Journal of Surgical Research·R V MaierJ R Fletcher
Oct 1, 1990·The Journal of Trauma·W UhlH G Beger
Jul 1, 1991·Journal of Applied Physiology·B A HolmG Enhorning
Nov 1, 1991·The American Review of Respiratory Disease·G R BernardJ J Vrbanac
May 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·M M GottschlichJ W Alexander
Apr 15, 1989·European Journal of Biochemistry·J PfeilschifterI Wiesenberg
Jan 1, 1988·Annals of the New York Academy of Sciences·S J Feinmark
Sep 1, 1988·The American Review of Respiratory Disease·A H StephensonA A Fowler
Jan 1, 1986·Intensive Care Medicine·H A BallP V Halushka
Nov 1, 1988·Current Problems in Surgery·B M JaffeK Kimura
Jan 15, 1987·Klinische Wochenschrift·W OettingerH G Beger
Jan 1, 1987·Intensive Care Medicine·G Deby-DupontR Goutier
Apr 1, 1985·Clinical Pharmacology and Therapeutics·H D ReinesP S Hunt
Jan 1, 1983·Prostaglandins·D F WoodwardM A Wasserman
Nov 1, 1984·Circulation Research·P J Kadowitz, A L Hyman
Jan 1, 1984·The American Journal of Emergency Medicine·J A CookP V Halushka
Jun 1, 1981·British Journal of Pharmacology·N Feuerstein, P W Ramwell
Jun 1, 1983·Canadian Journal of Physiology and Pharmacology·P Vadas, J B Hay
Apr 1, 1981·The Journal of Clinical Investigation·M M KrauszH B Hechtman
Dec 5, 1980·Biochimica Et Biophysica Acta·B A Freeman, W S Lynn

Citations

Dec 15, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W H ChoS-B Hong
Mar 29, 2001·Progress in Lipid Research·E A Capper, L A Marshall
Jul 11, 2002·Free Radical Biology & Medicine·Hartmut Kuhn, Astrid Borchert
Apr 30, 2003·Journal of Clinical Anesthesia·Gregor Theilmeier, Michael Booke
Apr 4, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A B J GroeneveldC E Hack
May 3, 2011·American Journal of Respiratory Cell and Molecular Biology·Gustavo Matute-BelloAcute Lung Injury in Animals Study Group
Jun 11, 2011·Critical Care : the Official Journal of the Critical Care Forum·Alessandro Pontes-ArrudaInvestigating Nutritional Therapy with EPA, GLA and Antioxidants Role in Sepsis Treatment (INTERSEPT) Study Group
Oct 24, 2012·Critical Care : the Official Journal of the Critical Care Forum·Michael AdamzikMatthias Hartmann
Aug 28, 2010·Nutrition Reviews·Julie M Martin, Renee D Stapleton
Jul 20, 2004·Current Opinion in Critical Care·John C Marshall
Jan 10, 2002·Critical Care Medicine·Saman Arbabi, R V Maier
Dec 1, 2000·Critical Care Medicine·M R Anderson, J L Blumer
Dec 13, 2005·Critical Care Medicine·J A Cook
Jun 24, 2004·Cellular Signalling·Yuhuan Xie, Kathryn E Meier
Jan 7, 2015·Expert Opinion on Emerging Drugs·Daniela ImpellizzeriSalvatore Cuzzocrea
Dec 25, 2012·Biochemical Pharmacology·Stephanie C Tucker, Kenneth V Honn
Sep 22, 2010·The Journal of Surgical Research·Aaron C BakerRichard Perez
Jun 24, 2010·Clinics in Perinatology·James L Wynn, Hector R Wong
Feb 28, 2009·European Journal of Pharmacology·Ioanna VasileiouLila Papadimitriou
Jul 7, 2007·Veterinary Immunology and Immunopathology·Rachael E EckertSamuel L Jones
Feb 13, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Francis H C TsaoKeith C Meyer
Jul 21, 2010·Critical Care Clinics·Renee D StapletonKonstantin Mayer
Oct 20, 2001·Disease-a-month : DM·P E Marik, J Varon
Aug 19, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Aya NishiokadaMakoto Usami
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·B A Mizock
Oct 11, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Barry A Mizock, Stephen J DeMichele
Apr 26, 2007·Journal of Intensive Care Medicine·Eddy Jean-Baptiste
Apr 14, 2005·Journal of Occupational Health Psychology·Laurent M LapierreJoanne D Leck
Jan 25, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yasin CiçekFikrettin Sahin
Aug 31, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W H ChoM K Lee
Feb 4, 2003·Journal of Lipid Research·Wolfgang DrobnikGerd Schmitz
Aug 25, 2001·Journal of Endotoxin Research·M J Dubois, J L Vincent
Nov 8, 2003·Pediatric Research·Albert CastellheimTom E Mollnes

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.