PMID: 8585927Nov 1, 1995Paper

Lipid mediators in the rat retina: light exposure and trauma elicit leukotriene B4 release in vitro

Current Eye Research
J J ReinbothC E Remé

Abstract

Light exposure not only elicits a visual response but may also alter functional and structural characteristics of the retina. Furthermore, light exposure can lead to reversible or irreversible lesions of photoreceptors and pigment epithelium. Previous studies in our laboratory have shown that light liberates arachidonic acid from retinal membrane phospholipids mainly by activating the phospholipase A2. In this study we show that light and trauma elicit the synthesis of leukotriene B4 in the isolated rat retina in vitro. Male albino rats were dark adapted for 36 h, isolated retinae were taken, incubated and exposed a) either to darkness or to 5,000 lux of cool white fluorescent light for 5, 10 or 15 min at 37 degrees C, b) either to darkness or to 5,000 lux of cool white fluorescent light for 15 min at 0 degrees C or c) either to darkness or to 5,000 lux of cool white fluorescent light for 15 min at 37 degrees C with a 5-lipoxygenase inhibitor (zileuton). Eicosanoids were extracted and leukotriene B4 levels were determined by radioimmunoassay. Removal of retinae and incubation in darkness caused a significant rise in leukotriene B4 levels with increasing incubation time. This rise was further augmented significantly after light ...Continue Reading

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Citations

Oct 6, 2006·The New England Journal of Medicine·Paulus T V M de Jong
May 12, 2011·PLoS Biology·Skyler L JackmanRichard H Kramer
Mar 19, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mauro LeonelliLuiz R G Britto
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Dec 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alma Barajas-EspinosaColin D Funk
Oct 20, 1998·Progress in Retinal and Eye Research·C E ReméA Wenzel

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