Lipid mediators of inflammation as novel plasma biomarkers to identify patients with bacteremia

The Journal of Infection
Kelvin K W ToKwok-Yung Yuen

Abstract

Rapid diagnostic tests for bacteremia are important for early treatment to improve clinical outcome. We sought to identify plasma biomarkers that can identify patients with bacteremia using an untargeted global metabolomic analysis. Plasma metabolomic profiles were analyzed for 145 adult patients with (cases) and without (controls) bacteremia using ultra-high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS). All metabolites were compared between cases and controls using a 2-tier filtering approach, and each metabolite underwent receiver operating characteristic (ROC) curve analysis. Individual metabolites that distinguish between cases and controls were characterized. Subgroup analysis was performed to identify metabolites with prognostic significance. After 2-tier filtering, 128 molecular features were identified to be potential biomarkers that could distinguish cases from controls. Five metabolites had an area under the ROC curve (AUC) of >0.8 in ROC curve analysis, including a sphingolipid, an acylcarnitine, a fatty acid ester, and 2 glycerophosphocholines. These metabolites could distinguish cases from controls in the unsupervised hierarchical clustering analysis. Subgroup analy...Continue Reading

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Citations

Mar 10, 2016·Journal of Mass Spectrometry : JMS·Elodie DuriezEric Ezan
Apr 24, 2016·Diagnostic Microbiology and Infectious Disease·Kelvin K W ToKwok-Yung Yuen
Sep 2, 2016·Biochemical and Biophysical Research Communications·Anna LindahlAnders Nordström
Mar 2, 2016·International Journal of Molecular Sciences·Susanna K P LauPatrick C Y Woo
Jan 22, 2018·Public Health Genomics·Nikolaos EvangelatosAngela Brand
Apr 27, 2018·Frontiers in Bioengineering and Biotechnology·Carlos Fernando Odir Rodrigues MeloRodrigo Ramos Catharino
Nov 21, 2017·Experimental Biology and Medicine·Robert T MalletRolf Bünger
Dec 31, 2018·Critical Care : the Official Journal of the Critical Care Forum·Pär I JohanssonKenneth B Christopher
Jul 22, 2019·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Xuedong ChenShaosong Zhou
Aug 31, 2021·PloS One·Ana Sofía Herrera-Van OostdamYamilé López-Hernández

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