Lipid membrane reorganization induced by chemical recognition

Biophysical Journal
J A LastD Y Sasaki

Abstract

Nanoscale structural reorganization of a lipid bilayer membrane induced by a chemical recognition event has been imaged using in situ atomic force microscopy (AFM). Supported lipid bilayers, composed of distearylphosphatidylcholine (DSPC) and a synthetic lipid functionalized with a Cu(2+) receptor, phase-separate into nanoscale domains that are distinguishable by the 9 A height difference between the two molecules. Upon binding of Cu(2+) the electrostatic nature of the receptor changes, causing a dispersion of the receptor molecules and subsequent shrinking of the structural features defined by the receptors in the membrane. Complete reversibility of the process was demonstrated through the removal of metal ions with EDTA.

References

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Citations

Sep 26, 2006·Biophysical Journal·Andrea L SladeChristopher M Yip
Aug 27, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Stefan S BordovskyDarryl Y Sasaki
Apr 14, 2007·The Journal of Chemical Physics·Zhencheng YeJianwen Jiang
Jan 2, 2007·Advances in Colloid and Interface Science·Adam Baszkin
Jan 12, 2019·PLoS Genetics·Lois M Douglas, James B Konopka
Dec 6, 2019·Chembiochem : a European Journal of Chemical Biology·Andrea Barba-BonAndreas Hennig
Jun 10, 2009·Journal of the American Chemical Society·Carl C HaydenDarryl Y Sasaki
Jun 12, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Howard SiuJennifer L Pincus
Apr 9, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Sean F GilmoreAtul N Parikh
Apr 3, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Darryl Y SasakiAndrew P Shreve

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