PMID: 15349009Sep 7, 2004Paper

Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment

Journal of Clinical Psychopharmacology
Daniel KopfMichael Deuschle

Abstract

Major depression increases cardiovascular risk despite lower cholesterol levels. Little is known about effects of antidepressants on metabolic risk factors. We studied lipoprotein composition, insulin sensitivity (quantitative insulin sensitivity check index), and saliva cortisol in 78 depressed patients before and after 35 days of amitriptyline or paroxetin treatment. Data were analyzed by principal component factor analyses and analysis of variance (ANOVA). At baseline, quantitative insulin sensitivity check index was inversely correlated with cortisol (r = -0.46; P = 0.005) in normal weight patients, with body mass index in overweight patients (r = -0.50; P < 0.001). In overweight patients, hypercortisolemia correlated inversely with total and low density lipoprotein cholesterol (eg, cortisol at 4:00 PM and low density lipoprotein cholesterol: r = -0.49, P = 0.002). After treatment, quantitative insulin sensitivity check index was unchanged. Triglycerides increased in responders to amitriptyline only (P < 0.05). Parameters of cholesterol metabolism improved slightly without differences between treatment groups (eg, high density lipoprotein: pre 43.5 +/- 12.0; post 47.6 +/- 13.0 mg/dL; P = 0.01; low density lipoprotein trigly...Continue Reading

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Citations

Nov 6, 2010·European Archives of Psychiatry and Clinical Neuroscience·Georgios PaslakisMichael Deuschle
Jul 28, 2011·Wiener medizinische Wochenschrift·Claudia RessChristoph F Ebenbichler
Jan 29, 2011·Current Hypertension Reports·Elisabeth A Lambert, Gavin W Lambert
Nov 28, 2013·Endocrine·Giacomo TirabassiGiorgio Arnaldi
Jul 17, 2007·Journal of Child and Adolescent Psychopharmacology·Nick C PatelMelissa P DelBello
Jun 16, 2006·Expert Opinion on Drug Safety·Roger S McIntyreSidney H Kennedy
Dec 9, 2009·Psychiatry Research·Jess G FiedorowiczWilliam H Coryell
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Nov 12, 2011·International Journal of Psychiatry in Medicine·Burkhard LudescherFritz Schick
Dec 17, 2008·International Journal of Psychiatry in Medicine·Burkhard LudescherGerhard W Eschweiler
Feb 27, 2007·Journal of Affective Disorders·Yi-Chyan ChenCheng-Hwang Perng
Oct 19, 2010·Journal of Psychopharmacology·Georgios PaslakisMichael Deuschle
Dec 13, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Robert P KauffmanRon Owens
Jan 21, 2018·European Archives of Psychiatry and Clinical Neuroscience·Johann SteinerHans-Gert Bernstein
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Aug 9, 2016·Obesity Research & Clinical Practice·Nattinee JantaratnotaiRoger S McIntyre

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