Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells

Cancers
Yoshiaki SunamiJörg Kleeff

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030, and the overall 5-year survival rate is currently less than 7%. Cancer cells frequently exhibit reprogramming of their metabolic activity. It is increasingly recognized that aberrant de novo lipid synthesis and reprogrammed lipid metabolism are both associated with the development and progression of various cancers, including pancreatic cancer. In this review, the current knowledge about lipid metabolism and lipid droplets in pancreatic cancer is discussed. In the first part, molecular mechanisms of lipid metabolism and roles of enzymes involved in lipid metabolism which are relevant for pancreatic cancer research are presented. Further, preclinical studies and clinical trials with drugs/inhibitors targeting cancer metabolic systems in cancer are summarized. An increase of our knowledge in lipid metabolism in pancreatic cancer cells and in tumor stroma is important for developing novel strategies of future individualized therapies of pancreatic cancer.

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Citations

Feb 6, 2019·International Journal of Molecular Sciences·Anika Dutta, Neelam Sharma-Walia
Apr 8, 2020·Cancers·Nurbubu T MoldogazievaAlexander A Terentiev
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Dec 30, 2020·Journal of Clinical Medicine·Pilar Espiau-RomeraPatricia Sancho
Mar 7, 2021·International Journal of Molecular Sciences·Mingming SongWenxiang Zhang
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Methods Mentioned

BETA
xenografts
xenograft
ubiquitination

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