Lipid metabolism in cancer: New perspectives and emerging mechanisms.

Developmental Cell
Lindsay A BroadfieldSarah-Maria Fendt

Abstract

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell death, and seed in secondary organs. An increased focus on cancer lipid metabolism has unveiled a number of mechanisms that promote tumor growth and survival, many of which are independent of classical cellular bioenergetics. These mechanisms include modulation of ferroptotic-mediated cell death, support during tumor metastasis, and interactions with the cells of the tumor microenvironment. As such, targeting lipid metabolism for anti-cancer therapies is attractive, with recent work on small-molecule inhibitors identifying compounds to target lipid metabolism. Here, we discuss these topics and identify open questions.

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Citations

Jul 27, 2021·Seminars in Liver Disease·Yi ZhouXin Chen
Nov 10, 2021·Current Opinion in Lipidology·Sonja C Stadler, Ralph Burkhardt

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