PMID: 1190646Jan 1, 1975Paper

[Lipid metabolism in rats fed a diet rich in various carbohydrates. I. Results after I.P. injection of lipogenic precursors].

Annales de la nutrition et de l'alimentation
R RozenR Lowy

Abstract

Male rats, Wistar CF strain, weighing 120 g at the beginning of the experiment, were fed during 7 months with one of the following diets, containing 72 p. 100 (w/w) carbohydrate: starch, fructose, glucose and sucrose. These diets were about 18% (w/w) in protein content and were conveniently balanced with respect to vitamins and mineral nutrients. After an overnight fast, the animals received by the i.p. way, 30 mn before their killing, one of the following lipogenic precursors: glucose (considered as the control treatment), fructose ethanol or acetate, thus forming 16 experimental groups. In their liver, heart and blood were determined the concentrations of 6 lipid compounds: triglycerides, non-esterified fatty acids, free, esterified and total cholesterol, phospholipide. a. The sucrose diet gave the heaviest animals, with a liver and heart which were the richest in triglyceride content. They had also the highest liver and blood cholesterol, but their blood phospholipid was the lowest. The starch diet also increased, compared to the glucose diet, liver and heart triglycerides and liver cholesterol. As regards the fructose diet, it had the same effects than the sucrose one in elevating liver weight, blood triglycerides and chole...Continue Reading

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