Lipid Nanoparticles Decorated with TNF-Related Aptosis-Inducing Ligand (TRAIL) Are More Cytotoxic than Soluble Recombinant TRAIL in Sarcoma

International Journal of Molecular Sciences
Ana Gallego-LleydaLuis Martinez-Lostao

Abstract

Sarcomas are rare and heterogeneous cancers classically associated with a poor outcome. Sarcomas are 1% of the cancer but recent estimations indicate that sarcomas account for 2% of the estimated cancer-related deaths. Traditional treatment with surgery, radiotherapy, and chemotherapy has improved the outcome for some types of sarcomas. However, novel therapeutic strategies to treat sarcomas are necessary. TNF-related apoptosis-inducing ligand (TRAIL) is a death ligand initially described as capable of inducing apoptosis on tumor cell while sparing normal cells. Only few clinical trials have used TRAIL-based treatments in sarcoma, but they show only low or moderate efficacy of TRAIL. Consequently, novel TRAIL formulations with an improved TRAIL bioactivity are necessary. Our group has developed a novel TRAIL formulation based on tethering this death ligand on a lipid nanoparticle surface (LUV-TRAIL) resembling the physiological secretion of TRAIL as a trasmembrane protein inserted into the membrane of exosomes. We have already demonstrated that LUV-TRAIL shows an improved cytotoxic activity when compared to soluble recombinant TRAIL both in hematological malignancies and epithelial-derived cancers. In the present study, we have...Continue Reading

References

May 31, 1996·The Journal of Biological Chemistry·R M PittiA Ashkenazi
Nov 5, 1997·The Journal of Biological Chemistry·M MacFarlaneE S Alnemri
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·I MonleónA Anel
Aug 16, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takahito HottaJunichiro Mizuguchi
Dec 26, 2006·Cancer Chemotherapy and Pharmacology·Tamer E FandyRakesh K Srivastava
Jun 26, 2007·Current Oncology Reports·Alexander J F LazarDina Lev
Dec 23, 2008·Biochemical Pharmacology·Patricia BalsasJavier Naval
Apr 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Suizhao WangDina Lev
May 13, 2010·Investigational New Drugs·Mark Andrew DicksonGary K Schwartz
May 28, 2010·Arthritis and Rheumatism·Luis Martinez-LostaoAlberto Anel
Jan 18, 2011·Cancer Letters·Harald WajantKlaus Pfizenmaier
Nov 26, 2011·Recent Patents on Anti-cancer Drug Discovery·Stella BernardiGiorgio Zauli
Jan 11, 2012·Biochemical Pharmacology·Luis Martinez-LostaoJavier Naval
Mar 1, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jason J LukeGary K Schwartz
Jan 22, 2013·Molecular Pharmaceutics·Diego De MiguelLuis Martinez-Lostao
May 4, 2013·British Journal of Pharmacology·O MicheauF Dufour
Sep 3, 2013·Biochemical and Biophysical Research Communications·Xiucheng LiChunping Zou
Jan 15, 2014·Cytokine & Growth Factor Reviews·Pamela M Holland
Jun 21, 2014·Cell Death and Differentiation·J LemkeH Walczak
May 15, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·D De MiguelL Martinez-Lostao
May 26, 2015·Expert Opinion on Therapeutic Targets·Bora LimWafik S El-Deiry
Mar 1, 2016·Recent Patents on Anti-cancer Drug Discovery·Diego De MiguelLuis Martinez-Lostao
Mar 5, 2016·Cell Death and Differentiation·D de MiguelL Martinez-Lostao
May 26, 2017·Nature Reviews. Cancer·Silvia von KarstedtHenning Walczak
Jun 3, 2017·BMC Medicine·Anna Maria FrezzaAlessandro Gronchi
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Aug 29, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Susmita SilShilpa Buch
Jan 25, 2021·QJM : Monthly Journal of the Association of Physicians·Mauro VasellaBong-Sung Kim

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