Lipid nanoparticles for chemotherapeutic applications: strategies to improve anticancer efficacy

Expert Opinion on Drug Delivery
Xia LinXing Tang

Abstract

Chemotherapy remains the major form of treatment for cancer. However, chemotherapy often fails due to a variety of barriers, resulting in a limited intratumoral drug disposition. Recently, lipid nanoparticles (LNs, i.e., solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs)) have been shown to provide a favorable means for efficiently delivering drugs to tumor sites, while minimizing their side effects. The delivery of drugs to tumors is restricted by a series of barriers, including the tumor abnormalities, strong adverse effects and poor specificity of cytotoxic drugs, and the induction of multidrug resistance (MDR). The present review summarizes the strategies using SLNs and/or NLCs to improve the anticancer efficacy of cytotoxic drugs, including passive targeting, active targeting, long circulating and MDR reversing. Specifically, the most significant in vitro and in vivo results on the use of SLNs and/or NLCs are highlighted. The future success of SLNs and NLCs for administration of cytotoxic drugs will depend on their ability to efficiently encapsulate and release drugs, the possibility for large-scale production, selective tumor cells targeting and increased antitumor efficacy with reduced tissue toxic...Continue Reading

References

Aug 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H AhlströmL E Lörelius
Oct 1, 1993·Cancer Treatment Reviews·R PazdurM N Raber
May 20, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·S C YangC Z Yang
Sep 10, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G P ZaraM R Gasco
Sep 16, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A FundaròM R Gasco
Feb 13, 2001·International Journal of Pharmaceutics·A MigliettaM R Gasco
Jan 31, 2002·Annual Review of Medicine·Michael M Gottesman
Aug 15, 2002·International Journal of Pharmaceutics·R H MüllerS A Wissing
Nov 15, 2002·Trends in Endocrinology and Metabolism : TEM·Steven W J LambertsLeo J Hofland
Nov 26, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jian Xin WangZhi Rong Zhang
Jan 22, 2003·Advanced Drug Delivery Reviews·Alexander V KabanovDonald W Miller
May 23, 2003·Journal of Pharmaceutical Sciences·Katrijn BogmanJürgen Drewe
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yingjuan Lu, Philip S Low
Oct 22, 2003·Pharmaceutical Research·Seong Hoon JangJessie L S Au
Dec 10, 2003·Pharmaceutical Research·Joanna M KoziaraRussell J Mumper
Feb 18, 2004·Neoplasia : an International Journal for Oncology Research·Dagmar Högemann-SavellanoJames P Basilion
Feb 20, 2004·Nature·Timothy P PaderaRakesh K Jain
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M E R O'BrienUNKNOWN CAELYX Breast Cancer Study Group
Mar 17, 2004·Cancer Treatment Reviews·Kirsten J M SchimmelHenk-Jan Guchelaar
Apr 28, 2004·Advanced Drug Delivery Reviews·S A WissingR H Müller
Sep 8, 2004·Advanced Drug Delivery Reviews·Lisa Brannon-Peppas, James O Blanchette
Sep 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joanna M KoziaraRussell J Mumper
Sep 29, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·L SerpeG P Zara
Oct 29, 2004·Nature Reviews. Cancer·Carl-Henrik HeldinArne Ostman
Jan 15, 2005·Pharmaceutical Research·Phillip J StevensRobert J Lee
Jun 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·L Harivardhan ReddyR S R Murthy
Jul 15, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kopparam Manjunath, Vobalaboina Venkateswarlu
Sep 10, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Chao FangHong-Zhuan Chen
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew J PrimeauIan F Tannock
Mar 7, 2006·Nature Reviews. Drug Discovery·Gergely SzakácsMichael M Gottesman
Aug 29, 2006·Drug Discovery Today·Arun K IyerHiroshi Maeda
Nov 14, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ho Lun WongXiao Yu Wu

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Citations

Feb 18, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Slavomira DoktorovovaAmélia M Silva
Jul 31, 2013·Drug Design, Development and Therapy·Wolfgang Hohenforst-SchmidtJohannes Brachmann
Nov 17, 2012·International Journal of Pharmaceutics·Florent PerretMarc Le Borgne
Mar 5, 2014·Pharmaceutical Patent Analyst·Claudia CarboneRosario Pignatello
Jun 10, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xue ChenYa Cao

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